| RESEARCH ARTICLE |
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| Year : 2009 | Volume
: 3
| Issue : 1 | Page : 9-12 |
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Behavior of suspending and wetting agents in aqueous environment
Shashikant C Dhawale1, Sudhir G Wadodkar2, Avinash K Dorle2
1 Govt. College of Pharmacy, Karad, India
2 Department of Pharmaceutical Sciences, RTM Nagpur University, Nagpur, India
Correspondence Address:
Shashikant C Dhawale
Department of Biopharmaceutics, Govt. College of Pharmacy, Karad, Maharashtra - 415 124
India
DOI: 10.4103/0973-8398.49167
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This work describes the changes in viscosity, conductivity, pH, electrical conductivity, dielectric constant, zeta potential, UV, and IR spectra of aqueous solutions/dispersions of sodium carboxy methyl cellulose (CMC), Tween 80, and sodium lauryl sulphate (SLS) during aging at different temperatures. Significant reduction in viscosity ofh sodium CMC occurred during aging studies, while relatively small decrease in viscosity was seen with Tween 80 and SLS. Increment in specific conductivity was seen with aging of excipients. Significant increase of zeta potential was also seen with aging of samples. Concomitant shift in IR spectra of samples was observed with aging at 40°C. |
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