Asian Journal of Pharmaceutics
  Home  |  About us  |  Instructions  |  Search  |  Current issue  |  Archives  |  Submission  |  Subscribe  |  Contact  |  Login 
RESEARCH ARTICLE
Year : 2010  |  Volume : 4  |  Issue : 4  |  Page : 199-204

Formulation and in vitro characterization of alginate microspheres loaded with diloxanide furoate for colon- specific drug delivery


1 Department of Pharmaceutics and Pharmacology, Shri Ram Institute of Technology (Pharmacy), Jabalpur, India
2 Department of Medicinal Chem., SGSITS, Indore, India

Correspondence Address:
Deepak Jain
Near Bus Stand, Tejgarh, Damoh (M.P.)
India
Login to access the Email id


DOI: 10.4103/0973-8398.76742

Get Permissions

The aim of the research work was to develop cyst-targeted alginates microspheres of diloxanide furoate (DF) for the effective treatment of amoebiasis. Calcium alginates microspheres of DF were prepared using emulsification method using calcium chloride as a cross-linking agent. Alginate is a natural polysaccharide found in brown algae. Alginates are widely used in the food and pharmaceutical industries and have been employed as a matrix for the entrapment of drugs, macromolecules and biological cells. Alginate microspheres produced by the emulsification method using calcium chloride. Formulations were characterized for particle size and shape, surface morphology, entrapment efficiency, and in vitro drug release in simulated gastrointestinal fluids. XRD and differential scanning calorimetery were used to confirm successful entrapment of DF into the alginates microspheres. All the microsphere formulations showed good % drug entrapment (73.82΁1.99). Calcium alginate retarded the release of DF at low pH (1.2 and 4.5) and released microspheres slowly at pH 7.4 in the colon without colonic enzymes.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed5038    
    Printed136    
    Emailed7    
    PDF Downloaded25    
    Comments [Add]    
    Cited by others 5    

Recommend this journal