| RESEARCH ARTICLE |
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| Year : 2011 | Volume
: 5
| Issue : 4 | Page : 225-230 |
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Paclitaxel loaded poly(sebacic acid-co-ricinoleic ester anhydride)-based nanoparticles
Santosh B Totiger1, Jagadeesh G Hiremath2
1 Department of Pharmacology, NET Pharmacy, College, Raichur, Karnataka, India
2 Department of Pharmaceutics, School of Pharmacy, University of Nizwa, Birkat Al Mouz, Sultanate Oman
Correspondence Address:
Jagadeesh G Hiremath
Assistant Professor in Pharmaceutics, College of Pharmacy and Nursing, University of Nizwa, P.O. Box 33, Post Code 616 Birkat Al Mouz
Sultanate Oman
DOI: 10.4103/0973-8398.97120
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The main objective of the present study was to prepare paclitaxel (PTX)-loaded poly(sebacic acid-co-ricinoleic ester anhydride) (poly (SA-RA) 70:30 w/w)-based nanoparticles (NPs). PTX- Poly (SA-RA) NPs were prepared by solvent displacement technique. The prepared formulations were characterized in terms of particle size and distribution, surface morphology using Malvern laser analyzer, scanning electron microscope (SEM). Drug physical and chemical state were determined by Fourier transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD) and differential scanning calorimetry. The particles obtained were spherical in shape with a smooth surface and mean particle size in the range of 443-436 nm. The entrapped PTX within the polymer matrix was in the form of amorphous state. |
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