@article{Parashar_2022, title={Evaluation of Cytoprotective Effect of Silymarine, Rutin, and Catechin on Cyclophosphamide-Induced Toxicity on Brain, Heart, and Spleen in Mice}, volume={16}, url={http://www.asiapharmaceutics.info/index.php/ajp/article/view/4397}, DOI={10.22377/ajp.v16i2.4397}, abstractNote={<p>Aim: The aim of the present study was to evaluate the cytoprotective effect of silymarine (SIL), rutin (RUT),<br>and catechin against cyclophosphamide (CYP)-induced toxicity. Materials and Methods: The protocol for the<br>study includes a total of 36 balb c mice and divided into six equal groups. These groups were: Control, CYP<br>(25 mg/kg b.w., i.p), CYP + Amifostine (AMF) (200 mg/kg b.w., i.p), CYP + SIL (100 mg/kg b.w., oral), CYP +<br>RUT (50 mg/kg b.w., oral), and CYP + Catechin(40 mg/kg b.w., oral). AMF, SIL, RUT, and Catechin treatments<br>were performed for 14 days, while CYP was given till 10th day of the study. Cytotoxicity was measured followed<br>lipid peroxidation (LPO), antioxidant markers such as superoxide dismutase, reduced glutathione, catalase,<br>and examined the histology of brain, heart, and spleen in all groups. Results: During CYP treatment, all three<br>flavonoids increased the levels of antioxidant markers and reduced the level of LPO. The CYP toxicity in brain,<br>heart, and spleen has been reduced by flavonoids coadministration which can be clearly seen in results of LPO,<br>antioxidant markers, and also in results of histopathology. Conclusion: Our study demonstrated that SIL, RUT,<br>and catechin reduce the toxic effect of CYP and these compounds may serve as a safe medicinal supplement<br>during CYP chemotherapy in cancer treatment.</p>}, number={2}, journal={Asian Journal of Pharmaceutics (AJP)}, author={Parashar, Deepesh}, year={2022}, month={Jun.} }