@article{Butani_2022, title={A Systematic Approach for Dissolution Enhancement of Felodipine using Hydrophilic Polymers for Solid Dispersion Preparation}, volume={16}, url={http://www.asiapharmaceutics.info/index.php/ajp/article/view/4476}, DOI={10.22377/ajp.v16i3.4476}, abstractNote={<p>Aim: The aim of the study was to systematically explore hydrophilic polymers as carrier for dissolution<br>enhancement using central composite design of experiment. Materials and Methods: Felodipine was chosen as<br>drug prototype for this study. Influence of formulation and processing parameters such as drug: Polymer ratio,<br>solid content of feed solution, inlet temperature, and aspirator percentage was studied on evaluation parameters<br>such as percent yield and drug release of solid dispersions using a 34 central composite design of experiment.<br>Effect of incorporation of surface active agent like polysorbate 80 on further increasing the in vitro dissolution was<br>also studied. Results and Discussion: Conversion of crystalline drug into amorphous form in solid dispersions<br>was confirmed by Differential scanning study and X-ray diffraction studies. In vitro dissolution study showed<br>55–60 fold increase in drug release within 60 min for spray dried solid dispersion as compared to untreated drug.<br>In vitro drug release was enhanced to 64–70 fold as compared to drug when polysorbate 80 (Tween 80) was used<br>as co-carrier for solid dispersion preparation. On basis of preliminary comparative dissolution trials PVP K 30 was<br>selected as suitable carrier polymer for further trials. Outcome of design of experiment trials indicated that drug:<br>Polymer ratio has maximum influence on drug dissolution from solid dispersions. Higher the ratio, more the drug<br>release. Process yield is mainly dependent on feed solid concentration and aspirator speed. Low solid content of<br>spraying solution and higher aspirator speed is required to get good process yield. Conclusion: The current study<br>demonstrates that PVP K 30 is a suitable carrier polymer to generate stable solid dispersions to enhance drug<br>dissolution using spray drying technology. Selection of appropriate formulation and processing conditions such as<br>drug: polymer ratio, inlet temperature, aspirator speed and solid content of feed solution determines the quality,<br>and performance of the solid dispersions.</p>}, number={3}, journal={Asian Journal of Pharmaceutics (AJP)}, author={Butani, Dr. Shital}, year={2022}, month={Sep.} }