@article{Ahire_2022, title={Utilization of Melt Solidification Technique in the Development of Sustained Release Pastilles of BCS Class –III Anti-diabetic Drug}, volume={16}, url={http://www.asiapharmaceutics.info/index.php/ajp/article/view/4597}, DOI={10.22377/ajp.v16i4.4597}, abstractNote={<p>Aim: Basically, this research work focused to explore the use of solid lipid as alternative to polymers and solvent<br>free process for formulation of sustained release dosage form such as pastilles by making laboratory scale fabricated<br>melt solidification apparatus. Materials and Methods: Melt solidification technique was used for the formulation<br>of sustained release pastilles of metformin hydrochloride. For the optimization response surface methodology<br>Box–Behnken design were implemented. Results: The lab scale fabricated device was evaluated at 20G size of<br>needle and cooling plate temperature at 4°C.The formulated pastilles was characterized for their size and shape,<br>crushing strength, flow properties, contact angle, % friability, % drug content uniformity, and thermal properties by<br>differential scanning calorimetrty, evaluation of pore formation done by scanning electron microscopic study. The<br>in vitro dissolution study revealed sustained release through lipid matrix up to 8–10 h. More than 95% drug released<br>was observed at 10 h. The formulated Pastilles were somewhat spherical in shape and size in the range 2.5–3.5 mm;<br>however, the angle of contact of pastilles was found to be more than 115°. Pore former quantity plays key role, it was<br>enhanced the dissolution rate. Conclusion: Pastillation technique is very effective technique for the formulation of<br>pastilles with desired size, shape, crushing strength, contact angle, and with sustained release of drug.</p>}, number={4}, journal={Asian Journal of Pharmaceutics (AJP)}, author={Ahire, Sandip Barku}, year={2022}, month={Dec.} }