@article{Aminabee_2023, title={Influence of Allium sativum on Pharmacodynamics and Pharmacokinetics of Gliclazide in Normal Rabbits}, volume={17}, url={http://www.asiapharmaceutics.info/index.php/ajp/article/view/4718}, DOI={10.22377/ajp.v17i1.4718}, abstractNote={<p>Aim: In this chapter, the influence of selected dose of Allium sativum (84 mg/1.5 kg bd.wt) on the pharmacodynamics<br>and pharmacokinetics of selected dose of gliclazide (5.6 mg/1.5 kg bd.wt) was studied in normal rabbits. Materials and<br>Methods: Materials required were purchased from Sai Chemicals, Visakhapatnam, India. Inbred adult Wistar rabbits<br>of either sex were used for the study. Gliclazide (TD) was administered orally to all the rabbits. After a wash out period<br>of 1 week, the same groups of animals were administered with Allium sativum (84 mg/1.5 kg bd.wt.) orally. Again after<br>a further washout period of 1 week, the same group was administered with A. sativum (84 mg/1.5 kg bd.wt.) orally,<br>30 min before the administration of gliclazide (5.6 mg/1.5 kg bd.wt). Blood samples were withdrawn at 0, 1, 2, 3, 4, 6,<br>8, 12, 16, 20, and 24 h intervals from marginal ear vein puncture and were analyzed for blood glucose by GOD/POD<br>method in all the experiments and serum gliclazide. Results: A. sativum has found to enhance the hypoglycemic effect<br>of gliclazide. There was a considerable percent blood glucose reduction with gliclazide (5.6 mg/1.5 kg bd.wt) before<br>and after treatment with Allium sativum (104 mg/kg) in rabbits.Conclusion: The interaction between A. sativum and<br>gliclazide appears to be pharmacodynamic and pharmacokinetic in nature.</p>}, number={1}, journal={Asian Journal of Pharmaceutics (AJP)}, author={Aminabee, Shaik}, year={2023}, month={Mar.} }