TY - JOUR AU - Kallepalli, Pramadvara PY - 2018/08/18 Y2 - 2024/03/29 TI - A New Stability Indicating Liquid Chromatographic Method for the Quantification of Felodipine JF - Asian Journal of Pharmaceutics (AJP) JA - AJP VL - 12 IS - 02 SE - ORIGINAL ARTICLES DO - 10.22377/ajp.v12i02.2400 UR - http://www.asiapharmaceutics.info/index.php/ajp/article/view/2400 SP - AB - Introduction: Felodipine is used for the treatment of hypertension. In the present study a new stability-indicating RP-HPLC method has been established for the determination of Felodipine.in pharmaceutical dosage forms and the method was validated. Material and Methods: Shimadzu Model CBM-20A/20 Alite, UFLC system was used for the assay of Felodipine using a mixture of phosphate buffer (pH 7.0) and acetonitrile (20:80, v/v) as mobile phase with a flow rate of 1.2 ml/min (UV detection at 234 nm). Forced degradation studies were performed by exposing Felodipine to different stress conditions and the method was validated as per ICH guidelines. Results and Discussion: Felodipine is found to be more sensitive towards oxidative degradation. Conclusion: The proposed method is simple and economical and can be used for the determination of Felodipine in pharmaceutical formulations. ER -