TY - JOUR AU - Sandeep, D. S. PY - 2022/01/18 Y2 - 2024/03/28 TI - Ibuprofen Emulgels as Promising Topical Drug Delivery System - A Study of Formulation Design and In vitro Evaluation JF - Asian Journal of Pharmaceutics (AJP) JA - AJP VL - 15 IS - 04 SE - ORIGINAL ARTICLES DO - 10.22377/ajp.v15i04.4225 UR - http://www.asiapharmaceutics.info/index.php/ajp/article/view/4225 SP - AB - <p>Aim: Ibuprofen is BCS class-II drug with lower solubility and higher permeability. The present work was undertaken<br />to formulate ibuprofen emulgels with a view to enhance the bioavailability and to make a suitable topical drug<br />delivery system. Methods: Xanthan gum was used as gelling agent in different concentrations. Ibuprofen was<br />dissolved in ethanol and propylene glycol. The oily phase was prepared with liquid paraffin. The formulated<br />emulgels were subjected for appearance, pH, spreadability, swelling index, rheological study, drug content, and<br />drug release parameters, and the optimized batch was evaluated for particle size and in vitro skin irritation study<br />by HET- CAM test. Results: The prepared emulgels showed satisfactory results for the evaluation parameters.<br />The emulgel IG-4 emerged as optimized formulation with higher drug release which had good mean particle size<br />and also found to be non-toxic and non-irritant with the obtained results of HET-CAM test. Conclusion: Emulgel<br />can be promising topical drug delivery approach for ibuprofen to enhance the bioavailability with better patient<br />compliance.</p> ER -