TY - JOUR AU - Sharma, Prachi PY - 2022/09/15 Y2 - 2024/03/28 TI - Formulation and Evaluation of Trolamine Salicylate Microemulsion JF - Asian Journal of Pharmaceutics (AJP) JA - AJP VL - 16 IS - 3 SE - ORIGINAL ARTICLES DO - 10.22377/ajp.v16i3.4487 UR - http://www.asiapharmaceutics.info/index.php/ajp/article/view/4487 SP - AB - <p>Aim: The aim of this study was to formulate and perform optimization, characterization, and in-vitro evaluation<br>of microemulsion containing trolamine salicylate (TMS) an anti-inflammatory agent for topical application.<br>Materials and Methods: Microemulsion formulations of TMS were prepared from optimized microemulsion and<br>effects of formulation variables such as solubility in different oils, surfactants and co-surfactants were assessed.<br>Oleic acid was selected as oil phase, tween-80, and ethanol as surfactant and cosurfactant, respectively. From the<br>ternary phase diagrams of surfactant (Tween 80)/cosurfactant (Ethanol) 1:1 ratio and oil (oleic acid), TMS-loaded<br>microemulsion formulation A6* was selected on the basis of clarity. Results and Discussion: The microemulsion<br>formulation A6* was found to be optically clear, transparent, and elegant in appearance, when compared to the<br>other microemulsion formulations with pH values of 5.3–6.5 were showing suitability for topical preparations.<br>The transmission electronic microscopy image of A6* showed that globules were spherical in shape, smooth<br>surface, and indicated the existence of an isotropic dispersion of spherical droplets, leading to the assumption<br>of inverse micelles because of the proportion of the constituents. Particle size of 297 nm indicates that there is<br>a chance that the number of vesicles can interact with a fixed area of stratum corneum, thereby increasing the<br>efficiency in percutaneous uptake. During Ex-vivo permeability study, the flux values and permeability coefficient<br>of TMS Microemulsion (A-6*) were found to be 6.518 μg/cm2 h and 3.259 cm.h-1. The highest cumulative drug<br>release for formulation A*6 was 95.048 ± 0.032% in 8 h. Conclusion: Microemulsion has low interfacial tension<br>and allows excellent contact with skin surface, with the vehicle filling even wrinkles and microscopic gaps. This<br>enhances the vehicle skin drug transfer. They have been used to improve the bioavailability of various poorly<br>soluble drugs including non-steroidal anti-inflammatory drugs. The formulation was in nano range and hence the<br>penetrability of the drug can be increased. Since this type of formulations can be easily developed and prepared;<br>therefore, they can be of great help for the drugs that have less permeation across the skin. Among the distinctive<br>formulations, A6* showed promising results, with respect to drug entrapment and percentage drug release.</p> ER -