TY - JOUR AU - Kori, Dr. Mohan Lal PY - 2022/09/15 Y2 - 2024/03/28 TI - Topical Delivery of Emulsomal Gel for the Management of Skin Cancer JF - Asian Journal of Pharmaceutics (AJP) JA - AJP VL - 16 IS - 3 SE - ORIGINAL ARTICLES DO - 10.22377/ajp.v16i3.4492 UR - http://www.asiapharmaceutics.info/index.php/ajp/article/view/4492 SP - AB - <p>Aim: The aim of the present study was to develop and characterize lipid vesicular gel for managing skin<br>cancer through topical route, because on the delivery of intact drug molecule, it distributed between normal<br>cell and cancerous cell, leading to unacceptable side effects and also require high dose of drug to treat.<br>Materials and Methods: Developed gel base with varying concentration of polymers and prepared emulsomes<br>was incorporated in gel base, and then, emulsomal gel was evaluated for different parameters such as pH<br>determination, viscosity, spreadability, homogeneity, and stability studies. The optimized emulsomal gel was<br>done for their in vitro and in vivo drug release study. Results: The optimization of gel base was performed<br>for different concentrations of Carbopol 934, methyl paraben sodium, glycerine, polyethylene glycol, and PVP.<br>Emulsomal gel was prepared by distribution of emulsomes into the gel base. Physical analysis demonstrated that<br>the resulting emulsomal gel had a light yellow color and was uniform and smooth when applied. The optimized<br>emulsomal gel formulations were shown to be appropriate for all other characterization parameters, such as pH,<br>viscosity, spreadability, and homogeneity. The in vitro drug release study investigation was revealed an improved<br>emulsomal gel, showed a sustained profile over a 12 h period. Stability studies of emulsomal gel in terms of<br>residual drug content and particle size indicated that at 25 ± 2°C temperature formulation, &lt;2% degradation was<br>observed over the 45 days. Skin irritation study and in vivo study were performed for developed emulsomal gel<br>formulation. The emulsomal gel composition has been shown to be non-irritant to the skin. Hence, emulsomal<br>gel represents promising result for improving the bioavailability of anti-cancerous drugs; moreover, emulsomal<br>gel produces sustained drug release. Thus, the presented system explores the favorable alternative to conventional<br>chemotherapy for the management of skin cancer through topical delivery. Conclusion: From the overall study, it<br>was concluded that the methotrexate emulsomal gel was successfully formulated and evaluated.</p> ER -