TY - JOUR AU - Kakad, Sudarshan B. PY - 2022/09/15 Y2 - 2024/03/28 TI - Effect of Hydrophilic Polymer and Binder on Drug Release of Metformin HCL in Sustained-Release Matrix Tablet JF - Asian Journal of Pharmaceutics (AJP) JA - AJP VL - 16 IS - 3 SE - ORIGINAL ARTICLES DO - UR - http://www.asiapharmaceutics.info/index.php/ajp/article/view/4512 SP - AB - <p>Aim: The aim of this study was to develop a sustained release formulation containing Metformin HCl.<br>Methods: The sustained-release Metformin HCl tablet was prepared by wet granulation technique, using different<br>grades of hydroxyl propyl methylcellulose (HPMC) in different concentration and by varying binder concentrations.<br>Formulation optimization was done by three ways to select optimum formula for preparing sustained-release matrix<br>tablet. The trail batches were prepared by varying the concentration of the binder and hydrophilic polymers, and<br>they were all analyzed for pre-and post-compression parameters. To determine the concentration of HPMC K4M<br>in the first step, three trial batches are produced. The following three batches are, then, analyzed to measure the<br>concentrations of HPMC K15M and K100M in the second and third steps, respectively. The HPMC amount was<br>optimized at 240 mg. Results: Each optimized HPMC batch’s drug release was assessed in an in vitro drug release<br>trial using phosphate buffer solution at pH 6.8 and compared to the drug release of the commercial formulation.<br>Drug identification was performed by melting point determination, Fourier transform infrared, UV, and solubility<br>determination. After pre-compression and post-compression evaluation, we get the appropriate result in B3, B6, and<br>B9 batches. In vitro drug release of these three batches was studied and compare with the marketed formulation.<br>Formulation when compared to the reference sustained-release Metformin HCl tablet, batch B9’s drug release, was<br>very similar. Batch B9 is therefore an optimized formulation. Conclusion: The hydrophilic polymer HPMC K100M<br>is useful for making tablets of metformin HCl with sustained-release. With an increase in hydrophilic polymer<br>content, the drug release was prolonged, and the PVP K30 binder gave the tablet the right amount of hardness.</p> ER -