TY - JOUR AU - Kola, Venu PY - 2022/12/15 Y2 - 2024/03/29 TI - Development and Evaluation of the Transdermal Drug-delivery System of Isradipine using Various Natural Polymers JF - Asian Journal of Pharmaceutics (AJP) JA - AJP VL - 16 IS - 4 SE - ORIGINAL ARTICLES DO - 10.22377/ajp.v16i4.4601 UR - http://www.asiapharmaceutics.info/index.php/ajp/article/view/4601 SP - AB - <p>Introduction: Transdermal applications, relative to other routes, are non-invasive, requiring the simple adhesion of<br>a “patch” resulting in better patient compliance, improved bioavailability of a drug, and easy treatment termination.<br>Hence, this investigation was aimed at delivering isradipine across intact skin as a membrane-moderated transdermal<br>therapeutic system of Eudragit RL100, Eudragit RS100, and Eudragit E100. Materials and Methods: An UV<br>spectrophotometric analytical method was developed for isradipine using a double UV spectrophotometer. The<br>method was validated for linearity, accuracy, and precision. Isradipine was determined in triplicate by standard<br>techniques. In vitro release studies in triplicate was conducted in Keshary-Chien diffusion cells across depilated rat’s<br>abdominal skin. Hypersensitivity reaction testing on depilated rabbit’s skin was conducted. Stability of the drugs was<br>studied under accelerated conditions recommended by ICH (40°C/75% R.H) for 90 days. Drug content was obtained<br>periodically and compared. Log Kp of isradipine was found to be –5.337. Flux obtained from basic in vitro release<br>(1 mg/ml) studies of isradipine was found to be 0.081 mg/cm2/h (r = 0.985). Results: The flux from isradipine from<br>reservoir gels IX and IA was found to be 0.034 mg/cm2/h (r = 0.985) and 0.033 mg/cm2/h (r = 0.987), respectively.<br>The flux of membrane-moderated systems of isradipine IXRL, IARL, IXRS, IARS, IXE, and IAE was found to be<br>0.022 mg/cm2/h (r = 0.977), 0.021 mg/cm2/h (r = 0.979), 0.020 mg/cm2/h (r = 0.977), 0.020 mg/cm2/h (r = 0.978),<br>0.019 mg/cm2/h (r = 0.975), and 0.016 mg/cm2/h (r = 0.970), respectively. Isradipine permeates greater from xanthan<br>gum (IX) gel compared to almond gum gel and lowest flux of the series was found to be from almond gum. Kp also<br>tends to decrease. It was understood from the investigation that IX and almond gum can be used as drug reservoirs<br>and Eudragit RL100, Eudragit RS100, and Eudragit E100 can be exploited as rate controlling polymeric membrane.<br>Conclusion: The formulations released the drug in adequate amount and it is also contemplated in this study that<br>even when used on human skin therapeutic concentration could be achieved in the treatment of hypertension.</p> ER -