TY - JOUR AU - Soujanya, C. PY - 2022/12/15 Y2 - 2024/03/28 TI - Development of Controlled-Release Formulation to Improve Bioavailability of Esomeprazole JF - Asian Journal of Pharmaceutics (AJP) JA - AJP VL - 16 IS - 4 SE - ORIGINAL ARTICLES DO - 10.22377/ajp.v16i4.4602 UR - http://www.asiapharmaceutics.info/index.php/ajp/article/view/4602 SP - AB - <p>Aim: The aim of this study was to release the active drug immediately after oral administration, to acquire<br>quick, and enter systemic drug absorption. Such immediate-release products result in comparatively rapid<br>drug absorption and onset of associated pharmacodynamic effects. Materials and Methods: The prepared<br>esomeprazole CR tablets were evaluated for the dissolution studies in acid buffer (pH-1.2) for 2 h, 4.5 pH<br>acetate buffers for 2 h, 6.8 pH phosphate buffers for 8 h, and 7.4 pH phosphate buffers for 12 h % drug<br>release that was calculated at various time intervals. Results and Discussion: The present study was aimed<br>to developing controlled-release tablets of esomeprazole using various polymers. All the formulations were<br>evaluated for physicochemical properties and in vitro drug release studies. Conclusion: The current research<br>work envisaged was an attempt to development of controlled-release formulations of esomeprazole to improve<br>bioavailability.</p> ER -