TY - JOUR AU - Panga, Shyam PY - 2022/12/15 Y2 - 2024/03/28 TI - Development and Characterization of Self-nano-emulsifying Drug-delivery System for Oral Delivery of Verapamil JF - Asian Journal of Pharmaceutics (AJP) JA - AJP VL - 16 IS - 4 SE - ORIGINAL ARTICLES DO - 10.22377/ajp.v16i4.4610 UR - http://www.asiapharmaceutics.info/index.php/ajp/article/view/4610 SP - AB - <p>Introduction: The present study deals with the development and characterization of self-nano-emulsifying drugdelivery<br>system (SNEDDS) to improve the oral bioavailability of water-insoluble biopharmaceutical classification<br>system Class II drug verapamil. The objectives of the study are to develop SNEDDS of verapamil and to characterize for<br>particle size, self-nano-emulsification, and dissolution enhancement. Solubility of verapamil was determined in various<br>oils, surfactants, and cosurfactants. Materials and Methods: Captex 355 was selected as an oil phase, acrysol K140<br>as surfactant, and PEG400 as cosurfactant due to their higher solubilization effect. Results: Various formulations were<br>prepared by simple mixing followed by vortexing. From studies, the optimized SNEDDS formulation was composed<br>of verapamil (9.13% w/w), captex 355 (23.41% w/w), acrysol K140 (51.62% w/w), and PEG 400 (11.58% w/w). The<br>selected SNEDDS could be self-emulsified without precipitation on simple mixing. The mean particle size of the<br>SNEDDS was 148.7 nm and percent drug content was 99.66. The in vitro dissolution of verapamil from SNEDDS was<br>found to be significantly higher (95.4 ± 2.07) in comparison to the marketed tablet (64.8 ± 1.36) and pure drug (52.5<br>± 1.65) in 0.1 N HCl as dissolution medium. Conclusion: The results indicate that SNEDDS of verapamil, due to its<br>nanosized, has potential to enhance the absorption of drug due to its higher dissolution.</p> ER -