TY - JOUR AU - Parihar, Ashwinee PY - 2022/12/15 Y2 - 2024/03/28 TI - Development of Innumerable, Expectedly Safe, and Aqueous Systems to Make Intramuscular Aqueous Injections (Solutions) of Poorly Water-soluble Drugs using Mixed Solvency Concept JF - Asian Journal of Pharmaceutics (AJP) JA - AJP VL - 16 IS - 4 SE - ORIGINAL ARTICLES DO - 10.22377/ajp.v16i4.4611 UR - http://www.asiapharmaceutics.info/index.php/ajp/article/view/4611 SP - AB - <p>Background: The primary goal of this research is to investigate the concept of mixed solvency in terms of<br>developing a large number of safe solvent systems for aqueous intramuscular injections that include water-soluble<br>additives. As a result, pharmaceutical industries can use these solvent systems to provide intramuscular injections<br>of drugs that are poorly water-soluble. Safe solubilizers’ solubilizing properties can be utilised to improve the<br>solubility of poorly water-soluble drugs. Objective: The main purpose of this research is to provide pharmaceutical<br>manufacturers with novel approaches for aqueous IM injections. Materials and Methods: In the present study,<br>we employed sodium benzoate, sodium acetate, sodium citrate, valine, l-lysine, arginine, ethanol, Tween 80 and<br>benzoic acid as solubilizers and ornidazole, paracetamol, aspirin, salicylic acid, gatifloxacin, naproxen, meloxicam,<br>furosemide, piroxicam, acyclovir, fenofibrate, indomethacin, norfloxacin, and nimesulide. Furosemide was selected<br>as the drug for the formulation of a typical aqueous IM injectable solution. For the drug identification, melting<br>ranges were determined all the drugs using melting point apparatus (Analab Scientific). UV identification was also<br>done for all drugs using UV-visible spectrophotometer (Shimadzu 1700). The pH of blend was estimated using pH<br>meter (Cyber Scan). Drug and excipient interference studies were performed before formulation using UV-visible<br>spectrophotometer. Drug and excipient interference studies also done before the formulation. The composition<br>of formulation is L-lysine (3% w/v), sodium acetate (10% w/v), arginine (10% w/v), and Tween 80 (5% w/v).<br>Results: By the solubility studies in different blends, the possibility of some IM injection solution can prepare such<br>as furosemide (20 mg/2 ml), piroxicam (20 mg/2 ml), repaglinide (16 mg/3 ml), indomethacin (25 mg/ml), and<br>acyclovir (20 mg/3 ml) can be produced. Furosemide: Chemical, physical, and freeze thaw studies were performed<br>for the stability study of formulation. The formulation gives satisfactory results during physical and chemical<br>stability studies. The pH of formulation was also performed and it was found similar to the pH of blend (pH-7).<br>Conclusion: From this research work, it is clear that mixed solvency concept can be employed to develop a large<br>numbers of expectedly safe aqueous IM injection solution type aqueous solvent systems for poorly water-soluble<br>drugs. Thus, solubilizing power of safe additives can be employed to make marketable aqueous IM injections.</p> ER -