@article{Madan_Kadam_Bandavane_Dua_2014, title={Formulation and evaluation of microspheres containing ropinirole hydrochloride using biodegradable polymers}, volume={7}, url={https://www.asiapharmaceutics.info/index.php/ajp/article/view/342}, DOI={10.22377/ajp.v7i4.342}, abstractNote={The present work relates with developing long acting sustain release microspheres of ropinirole hydrochloride (RPN) for<br />treatment of Parkinson’s disease, that will sustain drug release up to 1 month. Biodegradable microspheres of RPN were<br />prepared by using two different polymers (poly lactic co glycolic acid [PLGA] 50:50 and PLGA 75:25) employing double<br />emulsion (W/O/W) solvent evaporation method. Preliminary optimization of process parameter was done for concentration<br />of polyvinyl alcohol (PVA) solution, stirring speed, temperature of PVA solution, ratio of the drug to polymer (D/P) and<br />ratio of internal phase to external phase volume (IP/EP). All formulations were evaluated for particle size, percentage yield,<br />entrapment efficiency (EE), shape etc. Formulation E3 and E4 shows maximum EE. % in vitro drug release per day of E3 and<br />E4 batch was studied. The RPN was incorporated successfully in microspheres prepared with 0.5% w/v PVA at 8000 RPM<br />stirring speed, 20°C processing temperature, 1:4 drug polymer ratio and 1:30 IP/EP ratio, which provides sustained release<br />up to 4 weeks with better efficacy and patient compliance and can be employed as an alternative to existing oral medications.<br />Key words: Entrapment efficiency, poly lactic co glycolic acid 50:50, polyvinyl alcohol, solvent evaporation, sustained release}, number={4}, journal={Asian Journal of Pharmaceutics (AJP)}, author={Madan, Jyotsana R. and Kadam, Vinod and Bandavane, Sudarshan and Dua, Kamal}, year={2014}, month={Oct.} }