@article{Upadhye_2022, title={A Comparative Study of Two Different Taste Masking Approaches for Taste Masking of Azithromycin}, volume={15}, url={https://www.asiapharmaceutics.info/index.php/ajp/article/view/4223}, DOI={10.22377/ajp.v15i04.4223}, abstractNote={<p>Objective: Azithromycin is a BCS Class II drug having a poor water solubility and bitter taste, which leads to<br />poor patient compliance, especially in paediatric and geriatric patients. Thus in the present work taste masking was<br />done using two methods, solid dispersion (SD) and complexation using ion exchange resin and the two methods<br />were compared with respect to their efficiency of taste masking. Methodology: In this research work, SDs were<br />prepared by solvent evaporation method using ethanol as a solvent. Furthermore, drug resin complex containing<br />indion 234, a weak cation exchange resin was prepared by batch method. Both, SDs and drug resin complexes were<br />evaluated by FTIR, SEM, PXRD, and DSC studies and with respect to their micromeritic properties, solubility,<br />drug content, dissolution, and taste evaluation. Results and Discussion: The study showed that both the SDs as<br />well as drug resin complex showed improvement in taste as well as physicochemical properties, The drug content<br />and % drug release of the optimized batch prepared by SD method was found to be more that is 92.56 ± 0.75%<br />and 96.77%, respectively for SD5 (1:0.75) as compared to the optimized batch prepared by the ion exchange resin<br />that is 67.52 ± 0.51% and 75.25% for DRC4 (1:4).Taste evaluation studies also revealed a better taste masking with<br />SD as compared to drug resin complex. Thus, it can be concluded that due to its versatile utility SD method was<br />found to be the best and more efficient as compared to the ion exchange resin method for taste making of bitter<br />tasting drugs.</p>}, number={04}, journal={Asian Journal of Pharmaceutics (AJP)}, author={Upadhye, Kanchan P.}, year={2022}, month={Jan.} }