@article{Balamurugan_2022, title={Formulation and In Vitro, In Vivo Evaluation of Mucoadhesive Buccal Tablet of Felodipine}, volume={15}, url={https://www.asiapharmaceutics.info/index.php/ajp/article/view/4229}, DOI={10.22377/ajp.v15i04.4229}, abstractNote={<p>Aim: This study aims to formulate and evaluate the mucoadhesive buccal tablets of felodipine (FD) by direct<br />compression to improve the drug release and subsequently oral bioavailability. Materials and Methods: The<br />pure drug FD and excipient were obtained from manufacturing industries. The powder blend formulation<br />studies, moisture absorption study, residence time, ex vivo permeation, and in vivo drug release were studied.<br />Results and Discussion: The results for powder flow properties was found to be within the limits, moisture<br />absorption study was between 20.21% and 34.05% v/w residence time 7.45 ± 0.10 (h) ex vivo permeation<br />97.83 ± 0.52% and in vivo drug release was extended till 24 h and area under the curve 880.59 mg/h/l with an<br />Tmax at 8 h. Conclusion: The region in which it will remain in contact were perfectly done with appropriate<br />evaluation techniques (Residence time), the moisture absorption study was carried out to check how much<br />moisture the tablet can absorbed to release the drug and was found satisfactory. The ex vivo permeation study was<br />performed by Franz diffusion cell to check the drug permeation through buccal mucosa. The in vivo studies were<br />performed on New Zealand rabbits and can be concluded that the drug release from the formulated F6 was better<br />than the marketed application programing interface.</p>}, number={04}, journal={Asian Journal of Pharmaceutics (AJP)}, author={Balamurugan, K.}, year={2022}, month={Jan.} }