TY - JOUR AU - Bhattacharya, Sankha PY - 2020/06/09 Y2 - 2024/03/28 TI - Preparation and Evaluation of Diclofenac Sodium Niosomes Using Round Bottom Flask Method JF - Asian Journal of Pharmaceutics (AJP) JA - AJP VL - 14 IS - 2 SE - ORIGINAL ARTICLES DO - 10.22377/ajp.v14i2.3613 UR - https://www.asiapharmaceutics.info/index.php/ajp/article/view/3613 SP - AB - <p>Aim: The main objective of this study is to prepare and evaluate niosomes as a carrier for diclofenac sodium.<br />Niosomes are bilayer microparticles formed by self-association of non-ionic surfactant and cholesterol<br />after hydration in the aqueous phase. Materials and Methods: Niosomes of SPAN-60 and cholesterol were<br />prepared in three batches (A, B, and C) with different ratio (5:5, 6:4, and 7:3) using a round bottom flask<br />method. Prepared niosomes were evaluated for entrapment efficiency, particle size analysis, and morphology<br />and in vitro drug release study. Results and Discussion: The entrapment efficiency of all three formulations<br />was found to be 91.43%, 92.53%, and 92.33%, respectively. All formulations were observed under motic<br />microscope and particles were assumed to be spherical in shape. The average particle size of all the three<br />batches was analyzed by Zetasizer (Delsa C Particle Analyzer), and it was found that the batch C produced<br />the best nano-sized formulation with an average particle diameter of 311.6 nm. In vitro release study was<br />done using a dialysis bag and after 300 min of studies, batch C (7:3), which was found to have 68.6 ± 1.4%<br />cumulative drug release, which indicates controlled and steady drug release profiling of the formulation.<br />Conclusion: After comparing all three batches of evaluation results on the basis of drug entrapment, particle<br />size analysis, morphology, and in vitro drug release study, Batch C (7:3) formulation was considered as the<br />best formulation.</p> ER -