TY - JOUR AU - Singh, Nitin PY - 2021/11/01 Y2 - 2024/03/28 TI - Technology, Recent Advancement, and Application of Multiple Emulsions: An Overview JF - Asian Journal of Pharmaceutics (AJP) JA - AJP VL - 15 IS - 3 SE - REVIEW ARTICLES DO - 10.22377/ajp.v15i3.4143 UR - https://www.asiapharmaceutics.info/index.php/ajp/article/view/4143 SP - AB - <p>Multiple emulsions are complex polydispersed organizations where both oil-in-water and water-in-oil emulsion<br />are present simultaneously, which are stabilized by lipophilic and hydrophilic surfactants, respectively. To achieve<br />stable multiple emulsions, the proportion of these surfactants is critical. Between the two types of multiple<br />emulsions, water-in-oil-in-water (W/O/W) and oil-in-water-in-oil, the former has a wider range of applications and<br />is thus investigated in more depth. Multiple emulsion development, preparation procedures, and in vitro evaluation<br />methodologies have all been updated. Numerous elements impacting the stability of multiple emulsions, as well as<br />stabilization strategies, are explored in detail, with a focus on W/O/W type multiple emulsions. Multiple emulsions<br />are a possible carrier because they have desirable drug release mechanisms and rates, as well as a favorable<br />in vivo fate. It has a wide range of uses, including regulated, targeted distribution, flavor masking, bioavailability<br />augmentation, enzyme immobilization, and so on. In the microencapsulation process, several emulsions have also<br />been regarded an intermediate phase. They are the systems of increasing interest for the oral delivery of hydrophilic<br />drugs, which are unbalanced in the gastrointestinal tract such as proteins and peptides. It will provide a novel carrier<br />system for the administration of pharmaceuticals, cosmetics, and medicinal agents as procedures for preparation,<br />stabilization, and rheological characterization of multiple emulsions advance. Formulation, stabilization procedures,<br />and prospective uses of various emulsion systems are all considered in this assessment.</p> ER -