Rifampicin-Loaded Nanoparticles for Targeted Tuberculosis Therapy: Enhancing Delivery and Efficacy

Mohd Imran — Fri, 10 Jan 2025 00:00:00 +0000

Tuberculosis (TB) remains a major global health challenge, with limitations in the present drug regimens, including

poor bioavailability, systemic side effects, and the emergence of multidrug resistance. Rifampicin (RMP), a firstline anti-TB drug, suffers from rapid metabolism, limited tissue penetration, and poor targeting, necessitating

frequent dosing. Nanoparticle-based drug delivery systems offer a promising strategy to address these challenges

by enhancing targeted delivery, reducing toxicity, and improving therapeutic efficacy. A disruptive solution

to these challenges is presented by nanotechnology-based drug delivery systems. In this review, we examine

various studies on RMP-loaded nanoparticles, including polymeric nanoparticles, lipid-based nanocarriers (such

as liposomes and solid lipid nanoparticles), metallic nanoparticles, dendrimers, and micelles. These carriers

enhance the stability of the drug, facilitate its controlled release, and target its delivery to TB-infected tissues and

macrophages. Nanocarriers loaded with RMP have a high potential for transforming TB treatment because they

are more effective, have fewer systemic adverse effects, and are part of combating TB drug resistance on a global

scale.

An overview of the Importance of Quality Evaluation and Validation of Medicinal Plants

Dr. Shibu Narayan Jana — Fri, 09 Jan 2026 00:00:00 +0000

Phytoconstituents of medicinal plants and their derived formulations are evaluated for quality, safety, and efficacy. In recent years, most people are turning to the use of natural compounds or herbs or their formulations for the prevention or management of different disease conditions. Since phytotherapy is a common component of medical treatment, its efficacy and safety should be required, and the necessity of pharmacological, toxicological, and clinical trials is evident, as noted by Bauer and Tittel nearly 20 years ago. Different methods, such as physical, chemical, and biological, are used for the quality evaluation and standardization of herbal products and their formulations. For metabolomics profiling, a range of chromatographic and hyphenation with spectroscopic techniques, such as high-performance thin layer chromatography, high-performance liquid chromatography, liquid chromatography–mass spectrometry, gas chromatography–mass spectrometry, near infrareds, high-performance thin layer chromatography–mass spectrometry, and high-performance liquid chromatography–mass spectrometry, are the effective analytical approaches for quality measurement and standardization of medicinal plants and their extracts and herbal formulations. The processes of a quality evaluation and standardization paradigm are described in this article with the goal of ensuring and preserving the clinical efficacy, quality and safety, and consistent biologically active molecules of medicinal plants and their products.

Asian Journal of Pharmaceutics (AJP)

Rifampicin-Loaded Nanoparticles for Targeted Tuberculosis Therapy: Enhancing Delivery and Efficacy

An overview of the Importance of Quality Evaluation and Validation of Medicinal Plants