Herbal nanoparticles: A patent review

Namdeo R Jadhav, Trupti Powar, Santosh Shinde, Sameer Nadaf

Abstract


Design and development of herbal nanoparticles has become a frontier research in the nanoformulation arena. To update
researchers, an attempt has been made to review nanoformulation-based herbal patents. This article mainly covers
herbal medicines are used for the treatment of cardiovascular diseases, Parkinsonism, pulmonary diseases, proliferative
diseases, Alzheimer’s disease, diabetes, cancer therapy, anti-osteoporosis, and the like. It has been revealed that nanoparticles
of Curcumin have been widely designed to increase its bioavailability and for treatment of cancers like breast cancer, lung
cancer, pancreatic cancer, and so on. The common nanoformulated herbal medicines are Panax ginseng, Curcuma longa, Silybum
marianum, Withania somnifera, Gymnema sylvestre, Salvia miltiorrhiza, and the like, having a profound future potential.

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References


Nanoscience and Nanotechnologies: Opportunities and uncertainties.

Royal Society and Royal Academy of Engineering. The Royal Society.

Great-Britain: Latimer Trend Ltd, Plymouth, UK 2004. p. 116.

Rajendran R, Radhai R, Maithili N, Balakumar C. Production of

herbal-based nanoparticles for medical textiles. Int J Nanosci

;10:209-12.

Goyal A, Kumar S, Nagpal M, Singh I, Arora S. Potential of novel drug

delivery systems for herbal drugs. Ind J Pharm Educ Res 2011;45:225-35.

Ansari SH, Islam F. Sameem M. Influence of nanotechnology on herbal

drugs: A Review. J Adv Pharm Technol Res 2012;3:142-6.

How many different types of cancer are there? Cancer Research UK:

CancerHelp UK. Retrieved 11 May 2012. Available from: http://www.

cancerresearchuk.org.

Cancer Glossary. American Cancer Society. Retrieved September 11,

Available from: http://cancer.org.com.

What is cancer? National Cancer Institute. Retrieved September 11,

Available from: http://www.cancer.gov.

Gottesman MM. Mechanisms of cancer drug resistance. Annu Rev Med

;53: 615-27

Liu X, Kim CN, Yang J, Jemmerson R, Wang X. Induction of apoptotic

program in cell-free extracts: Requirement for dATP and Cytochrome.

Cell 1996;86:147-57.

Wilson KA, Waugh A, Chambers G, Grant A, Ross J. Ross and Wilson

Anatomy and Physiology in Health and Illness. 2nd ed. Edinburgh:

Churchill Livingstone; 2006. p. 53-4.

Silverstein A, Silverstein VB, Nunn LS. Cancer. Twenty-First Century

Books. Brookfield, Conn: Minneapolis, Minn. 2006. p. 11-2.

Sioka C, Kyritsis AP. Chemotherapy, hormonal therapy, and

immunotherapy for recurrent meningiomas. J Neurooncol 2009;92:1-6.

Cassileth BR, Deng G. Complementary and alternative therapies for

cancer. Oncologist 2004;9:80-9.

Tripathi KD. Essentials of Medical Pharmacology. 6th ed. Delhi: Jaypee

Brothers: Medical Publishers (P) Ltd; 2008. p. 819-34.

Kou WK, Kaohsiung KW. Water Soluble Extract from Plant of Solanum

Genus and the Preparation Process Thereof, and Pharmaceutical

Composition Containing the Water Soluble Extract. US Patent

A1, 9 December 2004.

Kou WK, Kaohsiung KW. Water Soluble Extract from Plant of Solanum

Genus and the Preparation Process Thereof, and Pharmaceutical

Composition Containing the Water Soluble Extract. EP Patent 1508334

B1, 23 February 2006.

Kou WK, Kaohsiung KW. Water Soluble Extract from Plant of Solanum

Genus and the Preparation Process Thereof, and Pharmaceutical

Composition Containing the Water Soluble Extract. US Patent

B2, 18 July 2006.

Singh CU. Novel Formulation of Digitalis Glycosides for Treating

Cell-Proliferative and Other Diseases. US Patent 20040082521 A1, 29

April 2004.

Desai NP, Soon-Shiong P, De TK. Combinations and modes of

administration of therapeutic agents and combination therapy. US

Patent 20070166388 A1, 19 July 2007.

Desai NP, Soon-Shiong P, De TK. Methods and compositions for treating

proliferative diseases. US Patent 007780984 B2, 24 August 2010.

Desai NP, Soon-Shiong P. Nanoparticles of paclitaxel and albumin in

combination with bevacizumab against cancer. US Patent 20100112077

A1, 6 May 2010.

Gorur A, Shanmugasundaram S, Shanmugasundaram S. Preparation of

agar bionanoparticles. IP Patent 376MAS200 3A, 6 January 2007.

Shanmugasundaram S, Krupakar P, Shanmugasundaram S. Preparation

of oligosaccharide bionanoparticles from moringa oleifera lam. IP Patent

MAS2003 A, 6 August 2007.

Liang W, Lou M, Si W. Nano anticancer micelles of vinca alkaloids

entrapped in polyethylene glycolated phospolipids. US Patent

A1, 26 February 2009.

Zale SE, Troiana G, Ali MM, Hrkach J, Wright J. Therapeutic polymeric

nanopartcles comprising vinca alkaloids and methods of making and

using them. US Patent 20100104655 A1, 29 April 2010.

Kurzrock R, Li L, Mehata K, Aggarawal BB. Liposomal curcumin for

treatment of cancer. US Patent 007968115 B2, 28 June 2011.

Sahoo SK, Mohanty C. Novel water soluble curcumin loaded

nanoparticulate system for cancer therapy. WO Patent 2011101859

A1, 25 August 2011.

Rigas B, Mackenzie G, Yu S, Huang L, Zhu R, Nie T. Combination

treatments and formulations for cancer. WO Patent 2011130486 A2,

October 2011.

Patel AR, Tiwari JK, Velikov KP. Particles comprising hydrophobic

polymer and hydrophobic phenolic compound. WO Patent 2012000757

A1, 5 January 2012.

Kim JH. Nanoparticle Composition for prevention of hair loss and

promotion of hair growth. US Patent 20100104646 A1, 29 April 2010.

Danek. Combination anti-cancer therapy. WIPO Patent WO/2013/066864

May 2013.

Linda E, Stepehn R. Growth inhibitory effects of nanoparticles

containing triterpene glycosides or triterpenes. US Patent 20130177627

July 2013.

Einbond L, Redenti S. Growth inhibitoyr effects of nanoparticles

containing triterpene glycosides or triterpenes. US Patent 2013/0177657

A1, 11 July 2013.

Liu S, Zaoli J, Cheng Y. Herbal composition phy906 and its use in

chemotherapy. US Patent 20130101688, 25 April 2013.

Crews L, Masliah E. Molecular mechanisms of neurodegeneration in

Alzheimer’s disease. Hum Mol Genet 2010;19:R12-20.

Pleckaityte M. Alzheimer’s disease: A molecular mechanism,

new hypotheses, and therapeutic strategies. Medicina (Kaunas)

;46:70-6.

Ashford JW. APOE genotype effects on Alzheimer’s disease onset and

epidemiology. J Mol Neurosci 2004;23:157-65.

Katzman R. Alzheimer’s disease. N Engl J Med 1986;314:964-73.

Geula C, Mesulam MM. Cholinesterases and the pathology of Alzheimer

disease. Alzheimer Dis Assoc Disord 1995;9 Suppl 2:23-8.

Lipton SA. Paradigm shift in neuroprotection by NMDA receptor

blockade: Memantine and beyond. Nat Rev Drug Discov 2006;5:160-70.

Stahl SM. The new cholinesterase inhibitors for Alzheimer’s disease,

part 2: Illustrating their mechanisms of action. J Clin Psychiatry

;61:813-4.

Chole GM, Frautschy SA. Bioavailable curcuminoids formulations for

treating Alzheimer’s disease and other age-related disorders. WO Patent

A2, September 13 2007.

Frautschy SA, Cole GM. Bioavailable curcuminoids formulations for

treating Alzheimer’s disease and other age-related disorders. US Patent

A1, 31 Dec 2009.

Desai K. Curcumin cyclodextrin combination for preventing or treating

various diseases. US Patent 20100179103 A1, 15 July 2010.

DiMauro TM. Methylated curcumin-resveratrol hybrid molecules for

treating cancer. US Patent 008350093 B2, 8 January 2013.

Mazed MA, Mazed S. Nutritional supplement for the prevention of

cardiovascular disease, Alzheimer’s disease, diabetis, and regulation

and reduction of blood sugar and insulin resistance. US Patent

B2, 13 September 2011.

Gupta SK. Controlled-release nano-diffusion delivery systems for

cosmetic and pharmaceutical compositions. US patents 20040208902

A1, 21 October 2004.

Gupta SK. Ion-pair delivery system for cosmetic and pharmaceutical

compositions. US Patents 20040228884 A1, 18 November 2004.

Nanbu T. Whitening cosmetic composition containing arbutin

nanoparticles. US Patent 20090069253 A1, 12 March 2009.

Wright DC. Micellar nanoparticles. US Patent 005629021 A, 13 May

Bakthavatchalam R, Blum CA, Brielmann H, Caldwell TM, Lombaert SD.

Substituted quinazolin-4-ylamine analogues as modulators of capsaicin.

WO Patent 2003062209 A2, 31 July 2003.

Bakthavatchatam R, Blum CA, Brielmann HL, Caldwell TM, De LS,

Hodgetts KJ, et al. 2-Substituted quinazolin-4-ylamine analogues as

capsaicin receptor modulators. WO Patent 2004055003, 7 January 2004.

Kanazawa K. Water-dispersible nanoparticle which contains blood

circulation promoter. US Patent 20090104291 A1, 23 April 2009.

Chaudhary M, Naithani V. Topical herbal formulation for treatment of

acne and skin disorder. US Patent 20110262499 A1, 27 October 2011.

Leighton HJ, Frangakis GJ. Methods and compositions for treating

inflammation of skin. US Patent 20130059019 7 March 2013.

Kim DH, Vaccaro AR. Osteoporotic compression fractures of the

spine; current options and considerations for treatment. Spine J

;6:479-87.

Alldredge BK, Kimble K, Anne M, Young, L Y., Kradjan WA, Guglielmo BJ.

Applied therapeutics: The clinical use of drugs. Philadelphia: Wolters

Kluwer Health/Lippincott Williams and Wilkins. 2009. pp. 101-3.

Avenell A, Gillespie WJ, Gillespie LD, O’Connell DL. Vitamin D

and vitamin D analogues for preventing fractures associated with

involutional and post-menopausal osteoporosis. Cochrane Database

Syst Rev 2005;20:CD000227.

Cockayne S, Adamson J, Lanham-New S, Shearer MJ, Gilbody S,

Torgerson DJ. Vitamin K and the prevention of fractures: Systematic

review and meta-analysis of randomized controlled trials. Arch Intern

Med 2006;166:1256-61.

Body JJ. How to manage postmenopausal osteoporosis? Acta clin Belg

;66:443-7.

Maurya R, Singh G, Murthy PS, Mehrotra S, Singh D, Bhargava B,

et al. Pharmaceutical composition containing butea isoflavones for

the prevention/treatment of bone disorders and a process for the

preparation thereof. WO Patent 2007099432, 7 September 2007.

Mousa SA, Qari MH, Ardawi MS. Composition and methods of natural

products in nanoformulations for the prevention and treatment of

osteoporosis. US Patent 20110104283 A1, 5 May 2011.

Canham L, Shabir QU, Loni A. Porous materials. US Patent 20110236493

A1, 29 September 2011.

Jankovic J. Parkinson’s disease: Clinical features and diagnosis. J Neurol

Neurosurg Psychiatry 2008;79:368-76.

Dauer W, Przedborski S. Parkinson’s disease: Mechanisms and models.

Neuron 2003;39:889-909.

Ceravolo R, Frosini D, Rossi C, Bonuccelli U. Impulse control disorders in

Parkinson’s disease: Definition, epidemiology, risk factors, neurobiology

and management. Parkinsonism Relat Disord 2009;15Suppl 4:S111-5.

Jodi N. Chloroquine derivatives for the treatment of parkinson’s disease.

US Patent 6417177 B1, 9 July 2002.

Jodi N. Compositions and methods for the treatment of parkinson’s

disease. EP Patent 1261340 B1, 13 May 2009.

Nobuhiro Y. Molecular mechanism of hyperlipidemia and future aspects

on the therapy. Nihon Rinsho 2001;59:170-4.

Aburdeineh SG, Aburdeineh HG. Methods of lowering blood cholesterol

via oral fenugreek seed extract compositions. US Patent 20050153001

A1, 14 July 2005.

Aburdeineh SG, Aburdeineh HG. Methods of lowering blood cholesterol

via oral fenugreek seed extract compositions. US patent 20080299235,

December 2008.

Gokharaju GR, Gokharaju RR, Golakoti T, Sengupta K, Bhupathiraju K,

Krishna V, et al. Anti-adipogenic compositions containing Piper betle

and Dolichos biflorus. US 20100203117 A1, 12 August 2010.

Medasani M, Divi SB. Picrorhiza Kurroa extract for prevention,

elimination and treatment of rna viruses and infection or diseases

caused by the same in humans, animals and in biotech industry. WO

Patent 2011027364 A2, 10 March 2011.

Medasani M, Divi SB. Picrorhiza Kurroa extract for prevention,

elimination and treatment of rna viruses and infection diseases. US

Patent 20120148569 A1, 14 June 2012.

Clark RA, Singer A, McMohan MF. Treatment of ischemic tissue. WO

Patent 2011047309 A2, 21 April 2011.

Nair AK, Parthasarathy K, Gokaraju GR, Bhuphatiraju K, Somushekara N,

Nanappan R, et al. Curcumoids and its metabolites for the application

in allergic ocular/nasal conditions. US Patent 2012/0010297 A1, 12

January 2012.

Nair AK, Parthasarathy K, Gokaraju GR, Bhuphatiraju K, Somushekara N,

Nanappan R, et al. Curcumoids and its metabolites for the application

in allergic ocular/nasal conditions. WO Patent 2010/109482 A2, 30

September 2010.

Kar SK, Akhtar F, Ray G, Pandey AK. Curcumin nanoparticles and methods

of producing the same. US Patent 20110190399 A1, 4 August 2011.

Nair AK, Chaniyilparampu RN, Bhupathiraju K, Gokaraju RR, Gokaraju GR,

Golakoti T. Process for nanoemulsification of curcumin and derivatives

of curcumin. US Patent 20110229532 A1, 22 September 2011.

Xu X, Yu J, Tong S, Zhu Y, Cao X. Formulation of silymarin with high

efficacy and prolonged action and the preparation method thereof. US

Patent 20110201680 A1, 18 August 2011.

Jacob CV. Synergistic composition for enhancing bioavaliability of

curcumin. US Patent 20120058208 A1, 8 March 2012.

Payne AJ, Kurien BT, Scofield RH. Solubilization of curcuminoid compounds

and products thereof. WO Patent 2013078477 A2, 30 May 2013.

Tengler M, Taskey P, Lockhart D, McMahen R. Composition and

methods of making sustained release liquid formulations. US Patent

, 4 April 2013.

Wertz CF, Ryde NP. Nanoparticulate compositions having lysozyme as

a surface stabilizer. US Patent 007459283 B2, 2 December 2008.

Hu Z, Che Y. Production of organic compound nanoparticles with

high repetition rate ultrafast pulsed laser ablation in liquid. US Patent

A1, 11 August 2011.

Mirkin CA, Giljohann DA, Daniel WL. Delivery of therapeutic agents

using oligonucleotide-modified nanoparticles as carriers. WO Patent

A1, 10 March 2011.

Mirkin CA, Giljohann DA, Daniel WL. Delivery of therapeutic agents

using oligonucleotide-modified nanoparticles as carriers. US Patent

A1, 8 November 2012.

Lillard JW, Singh R, Singh S. Novel nanoparticles for delivery of active

agents. US Patent 20070224280 A1, 27 September 2007.

Gogerddan P, Ceredigion A. Anti-inflammatory compounds. WIPO Patent

WO2013054070 18 April 2013.

Ross RF. Device for delivery of rheumatoid arthritis medication. US

Patent 2013144257 A1, 6 June 2013.

Banerjee R, Kaviratna A. Protein free surfactant composition for

pulmonary diseases and a process for preparing the same. WO Patent

A1, 14 June 2012.

Chen TD. Nano-particle production. US Patent 20060008498 A1, 12

January 2006.

Priem F, Jacquemond-Collet I. Pharmaceutical composition presenting

anti-inflammatory and anti-histaminic properties. EP Patent 2229940

A1, 22 September 2010.

Priem F, Jacquemond-Collet I. Pharmaceutical composition presenting

anti-inflammatory and anti-histaminic properties. WO Patent

A1, 23 September 2010.

Karnik R, Gu FX, Cannizzaro C, Khademhosseini A, Langer RS,

Farokhzad OC. Microfludic synthesis of organic nonoparticles. US

patent 20100022680 A1, 28 January 2010.

Spengler EG, Dahms GH. Composition and method employing

membrane structured solid nanoparticles for enhanced delivery of oral

care actives. US Patent 20060024248 A1, 2 February 2006.

Matuschek M, Ernst A, Köpsel C, Jager MB, Kleber A, Krohn M, et al. Use

of water-dispersible carotenoid nanoparticles as taste modulators, taste

modulators containing water-dispersible carotenoid nanoparticles, and

method for test modulation.US Patent 20100028444 A1, 4 February 2010.

Porter V, Morgan A, Prencipe M. Oral care composition. US Patent

, 17 January 2013.




DOI: http://dx.doi.org/10.22377/ajp.v8i1.324

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