Formulation, Optimization, and Evaluation of Bioadhesive Xanthan Gum Based Buccal Patch for Sustained Delivery of Ropinirole Hydrochloride

Kalyani Kayande

Abstract


Introduction: Parkinson’s disease is a neurological disorder in which there is a gradual loss of brain cells that make
and store dopamine. Ropinirole hydrochloride (ROPH) is an anti-Parkinson’s drug which undergoes extensively
first-pass metabolism, with oral bioavailability 45%. Aim: The study aimed to formulation, optimization, and
evaluation of ROPH buccal patch using xanthan gum (XG). Materials and Methods: Solvent casting method was
used to prepare mucoadhesive buccal patch ROPH using XG as a mucoadhesive polymer, polyvinylpyrrolidone
K90 as a film former and polycarbophil and hydroxypropyl methylcellulose K4M as a release retardant.
Results and Discussion: The dissolution studies showed sustained release of drug about 97.86% for 8 h following
Korsmeyer-Peppas model (r2=0.989, n = 0.199). The optimization of all prepared batches was carried out by 32
factorial designs, the optimized batch F3 showed acceptable physicochemical properties and having swelling
index 286.10%, mucoadhesive strength 26.90 g, tensile strength 0.04±0.01 N/mm2, and in vitro drug release
97.86%. Ex vivo permeability was carried out using sheep buccal mucosa and it was found to be increased by five
folds than that of formulation without penetration enhancer. After histopathological evaluation cellular membrane
was found to be intact and did not show any signs of necrosis. Conclusion: Thus, an attempt to formulate a stable
mucoadhesive buccal patch was made. The in vitro studies have shown that this is a potential drug delivery system
for ROPH with good stability and release profile.


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DOI: http://dx.doi.org/10.22377/ajp.v15i1.3956

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