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Background: Gastro retentive systems are retained in the stomach for a prolonged period. The objective of the present
study was to formulate gastro floating tablet of Baclofen respectively. Methods: The physicochemical parameters such
as hardness, weight variation, variability, in-vitro dissolution studies, and floating lag time (FLT) were performed to
optimize the formulations. Results: Post compression parameters were in pharmacopieal limits. The FLT of optimized
formulation was found <5 min and floated on the test media (0.1N HCL) for up to 24 h. Among Nine formulations, F4
formulation provides 99.62% drug was released at 24 h. Conclusions: The formulated floating tablets showed good
buoyancy properties, thus could be a promising formulation for improving bioavailability and decreasing drug toxicity.
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