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The catastrophic second wave of COVID-19 caused over 26 million cases in India making it the epicenter of
the global pandemic. The sudden surge in COVID-19 infections is intertwined with various variants including
B.1.617. Globally, health authorities have expressed major concerns that key mutations L452R and E484Q located
at the receptor-binding domain of the spike protein would have additive effects on SARS-CoV-2 evasion from the
vaccine-elicited antibodies. As India struggles with COVID-19 cases spiraling out of control, it is simultaneously
caught by escalating cases of “Black Fungus.” Researchers are hurrying to determine the many circulating
variants and to know the unknowns about biology and pathology of the mutating SARS-CoV-2 to analyze the
threat possessed by them.
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