SOLUBILITY ENHANCEMENT STRATEGIES FOR POORLY WATER-SOLUBLE DRUGS IN SOLID DISPERSIONS: A REVIEW

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D. K. SHARMA

Abstract

Solid dispersions have been employed to enhance the dissolut ion rates of poor ly water - soluble drugs.
Many approaches have been invest igated for the preparat ion of solid dispersions. This paper repor ts
various solubility enhancement strategies in solid dispersion. The approaches described are fusion (melting),
solvent evaporation, lyophilization (freeze drying), melt agglomeration process, extruding method,
spray drying technology, use of surfactant, electro static spinning method and super critical fluid technology.
The paper also highlights the potential applications and limitations of these approaches in solid
dispersions

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How to Cite
SHARMA, D. K. (2016). SOLUBILITY ENHANCEMENT STRATEGIES FOR POORLY WATER-SOLUBLE DRUGS IN SOLID DISPERSIONS: A REVIEW. Asian Journal of Pharmaceutics (AJP), 1(1). https://doi.org/10.22377/ajp.v1i1.734
Section
REVIEW ARTICLES