R, Natrajan
R Jadhav, Namdeo
R. Bhat, Mahesh, Sant Gajanan Maharaj College of Pharmacy, Mahagaon - 416 503, Gadhinglaj, Kolhapur, Maharashtra, India.
R. Madan, Jyotsana
Radhadevi, Nadimpalli
Radhika, Parasuram Rajam
Rafe, Md. Rajdoula, Department of Pharmacy, Southeast University, Dhaka - 1213, Bangladesh.
Raghavendra, R K
Raghu, K S
Raghuveer, Pathuri
Rahul, Joshi
Rai, Dr. Neeta
Rai, Neeta
Rais, Mohd Imran
Rajak, Ashutosh
Rajala Srikala, Rajala Srikala
Rajamani, Sumathi
Rajamanickam, Deveswaran
Rajarajan, S.
Rajawat, Prof. J. S.
Rajendra, Dr. S. V.
Rajendra, Dr. Wudayagiri
Rajendra, Jangde, University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur - 492 010, Chhattisgarh, India.
Rajitha, Koppula, Department of Pharmaceutics, St. Peters Institute of Pharmaceutical Sciences, Hanamkonda, Warangal - 506 142, Telangana, India.
Rajkumar, M
Rajput, Mithun Singh
Rajput, MS
Raju, K. Venkateswara
Raju, L
Raju, Senthilkumar
Ramana, M V
Ramasami, C.
Ramayanam, Navakanth Raju
Ramchand, Dhakar
Ramesh, Dr. K. V. R. N. S, RAK Medical and Health Sciences University, Ras Al Khaimah, Post Box No. 11172, United Arab Emirates
Ramesh, Dr. K. V. R. N. S., Department of Pharmaceutics, Ras al-Khaimah Medical and Health Sciences University, Ras al-Khaimah, UAE
Ramesh, K, Aim: The aim of the present research work was to enhance the rate of in vitro drug release profiles of poorly soluble Rilpivirine Hydrocloride (RH) by Spray drying technique. Rilpivirine is a non-nucleoside reverse transcriptase inhibitor of human immunodeficiency virus type-1 (HIV-1). Method: RH is belongs to BCS class-II. It is insoluble in water and practically insoluble across the pH range of 1 – 7.5. One of the major concerns with the formulation of RH is its poor solubility, which results into poor bioavailability after oral administration. Spray drying technique has been proven to be an efficient technique for conversion of poorly soluble crystalline form into highly soluble amorphous form and make it useful for formulating lab scale batches to commercial batches. Hence, Spray drying technique was chosen for reducing the % of crystallinity / or converting crystalline form into highly soluble amorphous form by spray drying technique. The organic dispersion comprising RH, hydrophilic carriers like Soluplus / Kollidon VA64 / Kolliphor SLS / Kolliphor P407 / Kollidon 30 at different ratios along with finer grade of microcrystalline cellulose (Avicel PH 105) was subjected to spray drying using Buchi spray dryer. Results & Discussion: The dissolution profiles of formulated product (RT2 & RT3) in FDA recommended dissolution media was compared against the dissolution profiles of corresponding innovator product. The rate of in vitro drug release was at faster and complete from test product as compared to Innovator product profiles i.e., EUDRANT™ 25 mg tablets. From the characterization of spray dried powder RSD8 by DSC and XRD concluded that % crystallinity of RH was reduced significantly. Conclusion: The obtained results suggested that Spray drying technique might be an efficacious approach in enhancing the therapeutic potential of Rilpivirine Hydrochloride.
Ramesh, K. V. R. N. S.
Rampure, M V
Ramu, Anne
Ranade, Mrs. Arati N.
Rangasamy, Manivannan
Rani, C
Rani, Shoba
Rani, T. Neelima, Institute of Pharmaceutical Technology, Sri Padmavathi Mahila Visvavidyalayam, Tirupati - 517 501, Andhra Pradesh, India.
Rao, K Chowdoji
Rao, K Purushotham
Rao, K. Chowdoji
Rao, K. Madhusudana
Rao, K. R. Koteswara
Rao, Monica RP
Rao, N G Raghavendra
Rao, V. Uma Maheswara
Rao, Vattikuti Uma Maheshwara
Rao Yarraguntla, Dr. Srinivasa, Vignan Institute of Pharmaceutical Technology, Visakhapatnam - 530 049, Andhra Pradesh, India.
Rao1, C G Geetha
Rashidi, Samaneh, Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Rashidi, Samaneh, Department of Medical Physics, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. (Iceland)
Rastogi, Vaibhav
Rastogi, Vaibhav, Faculty of Pharmacy, IFTM University, Moradabad - 244 001, Uttar Pradesh, India.
Rathi, Mohan
Rathnam, Grace, Department of Pharmaceutics, C.L. Baid Metha College of Pharmacy, Thoraipakkam, Chennai, Tamil Nadu, India.
Rathore, Garvendra S
Rathore, Mahendra Singh
RATHORE, MAHENDRA SINGH, B. R. Nahata College of Pharmacy, A SIRO and TePP Innovation Network Partner Recognized by Ministry of Science and Technology GOI, Mandsaur, MP, (India)
Ratna, J Vijaya
Ratnakar, Nayankumar C., Hemchandacharya North Gujarat University, Patan, Gujarat, India
Ratnakaram, Dr. Venkata Nadh
Ravi, Dr. Lokesh
Ravi, Valluru
Ravikumar, KG
Rawat, MS
Ray, Debajyoti
RD, Budhiraja
Reddy, Prof. K. Ramachandra
Reddy, Aduri Prakash
Reddy, Ajay Kumar
Reddy, Annapureddy Dasaratharami
Reddy, C Lakshmi Narayana
Reddy, D. Saikiran
Reddy, Dr. K. Bhaskar
Reddy, Dr. K. R. C.
Reddy, Dr. K. R. C., Department of Rasa Shastra, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Reddy, Dr. K. R. C., Department of Rasa Shastra, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
Reddy, Dr. M. Sunitha
Reddy, Dr. P. Dwarakanadha
Reddy, E. Sravanthi, Department of Pharmaceutics, Guru Nanak Institutions Technical Campus - School of Pharmacy, Hyderabad, Telangana, India.
Reddy, G. Lakshmi Narayana, RA ChemPharma Limited, Hyderabad, Telangana, India.
Reddy, K. R. C.
Reddy, K. R. C., Department of Rasa Shastra, Faculty of Ayurveda, IMS, BHU, Varanasi, Uttar Pradesh
Reddy, K. R. C., Department of Rasa Shastra, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi - 221 005, Uttar Pradesh, India.
Reddy, K. R. C., Department of Rasa Shastra, IMS, Banaras Hindu University, Varanasi, Uttar Pradesh, India
Reddy, K. Ramachandra
Reddy, Matta Nalini Krishna, Talla Padmavathi Pharmacy College, Warangal, Telangana, India.
Reddy, Prof. K. Rama Chandra
Reddy, Satish
Reddy, V. Sarovar
Reddy, V. Sarovar
Reddy, Yugendar
Renuka, J.
Reshetnikov, Evgeny A.
Reshetnikov, Evgeny A., Department of Medical Biological Disciplines, Belgorod National Research University, 85 Pobeda St., Belgorod, 308015, Russia. (Russian Federation)
Reza, Tahvilian
Rezaeisadrabadi, Dr. Mohammad
Riewpaiboon, Dr. Arthorn
RK, Maheshwari
Rode, Anuja
Rokhzadi, Mohammadzahed
Rompicharla, Narayanacharyulu
Roopchandani, Komal
Rosmalena, Rosmalena
Roy, Harekrishna
Roy, Harekrishna (India)
Rudrapal, Mithun

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