Effect of casting solvent and polymer on permeability of propranolol hydrochloride through membrane-controlled transdermal drug delivery system

Talasila Eswara Gopala Krishna Murthy, Vankayalapati Saikishore

Abstract


In the present work, cellulose acetate (CA), ethyl cellulose (EC), and Eudragit RS 100 (ERS100) films were prepared and evaluated as rate-controlling membranes for transdermal drug delivery systems. Acetone-methanol (8:2), chloroform-
methanol (8:2), dichloromethane-methanol (8:2), and ethyl acetate-methanol (8:2) were used as solvents in the preparation of films. Dibutyl phthalate or propylene glycol at a concentration of 40% w/w of the polymer was used as a plasticizer in the preparation of CA and EC films. Dibutyl phthalate at a concentration of 15% w/w of the polymer was used as a plasticizer in the preparation of ERS100 films. The solvent evaporation technique was employed for the preparation of CA and EC films, and the casting solvent technique was employed for the preparation of ERS100 films. The dry films were evaluated for physical appearance, thickness uniformity, folding endurance, water vapor transmission (WVT), drug diffusion, and permeability coefficient. Both WVT and drug diffusion rate followed zero-order kinetics. The mechanism of
drug release was governed by Peppas model.The diffusion exponent of release profiles (slope) has a value of 1.0360-1.3147 (n > 1), which indicates super case II transport diffusion. The results obtained in the present study thus indicated that the polymers and solvents used for the preparation of films have shown significant influence on the WVT, drug diffusion, and
permeability of the films.


Full Text:

PDF

References


Lee SJ, Kim SW. Temperature and pH-response swelling behavior of

poly (2-ethyl-2-oxazoline) chitosan interpenetrating polymer network

hydrogels. J Control Release 1987;82:3-6.

Arwidson H, Johanson B. Application of intrinsic viscosity and

interaction constant as a formulation tool for film coating. Int J Pharm

;76:91-7.

Abdul Aziz SA, Anderson W. The influence of casting solvent

composition on structure and permeability of acrylic-methacrylic ester

copolymer films. J Pharm Pharmcol 1976;28:801-5.

Spitel J, Kinget R. Preparation and evaluation of free films: Influence of

method of preparation and solvent composition upon the permeability.

Pharma Act Helv 1977;52:47-50.

Crawford RR, Esmerin OK. Effect of plasticizers on some physical

properties of cellulose acetate phthalate films. J Pharm Sci

;60:312-5.

Spitael J, Kinget R. Preparation and evaluation of free films: Influence

of plasticizers and filler upon the permeability. Pharma Acta Helv

;52:106-8.

Murad F. Good man and Gilman’s Pharmacological basis of therapeutics.

ln: Gilman AG, Rall WT, Nies SA, Taylor P, editors. 9th ed. New York:

International, Mc Graw Hill Co Inc.; 1996. p. 762-3.

Khurana R, Ahuja A, Khar RK. Development and evaluation of mucoadhesive films of miconazole nitrate. Indian J Pharm Sci 2000;62:447-53.

Kulkarni R, Doddayya H, Marihal S, Patil C, Habbu P. Comparative

evaluation of polymeric films for transdermal applications. Eastern

Pharmacist 2000;43:109-12.

Paranjyothy KL, Thampi PP. Development of transdermal patches

of verapamil hydrochloride using sodium carboxymethyl guar as a

monolithic polymeric matrix and their invitro release studies. Indian J

Pharm Sci 1997;52:49-54.

Indian Pharmacopoeia, Vol. II, 4th ed. New Delhi: The Controller of

Publications; 1996. p. 634.

Salomon CJ, Bravo SA, Lamas MA. In-vitro studies of diclofenac sodium controlled-release from biopolymeric hydrophilic matrices. J Pharm

Pharmaceut Sci 2002;5:213-9.

Wise DL. Hand book of pharmaceutical controlled release technology,

st ed. Cambridge: Marcel Dekker, Cambridge Scientific Inc.; 2005.

p. 187-8.




DOI: http://dx.doi.org/10.22377/ajp.v2i2.180

Refbacks

  • There are currently no refbacks.