Effect of cross-linking agent on the characteristics of celecoxib loaded chitosan microspheres

Hetal Paresh Thakkar, Rayasa Ramachandra Murthy

Abstract


The purpose of the present investigation was to compare the characteristics of the microspheres of chitosan prepared using two different cross-linking agents: viz. formaldehyde and glutaraldehyde and by simple heat treatment. Chitosan
microspheres were prepared by emulsification cross-linking method. Microspheres were characterized for entrapment efficiency, particle size, in-vitro drug release and surface morphology was studied by scanning electron microscopy. The
entrapment efficiency of the glutaraldehyde and formaldehyde cross-linked microspheres was significantly higher (P<0.05) than the heat-cross-linked microspheres. In-vitro drug release studies indicated that the microspheres cross-linked using glutaraldehyde showed slower release rate than those cross-linked with formaldehyde while the heat cross-linked microspheres showed the fastest release.


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DOI: http://dx.doi.org/10.22377/ajp.v2i4.195

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