Solubility and dissolution enhancement of HPMC ‑ based solid dispersions of carbamazepine by hot‑melt extrusion technique

Sharadchandra Dagadu Javeer, Purnima Dhanraj Amin


The objective of this study was to investigate solid dispersions (SDs) of poorly water soluble drug carbamazepine (CBZ),
prepared using low viscosity grade hydroxypropyl methyl cellulose (HPMC) (Methocel® E3 LV and Methocel® E5 LV)
by hot‑melt extrusion (HME) technology. Saturation solubility and dissolution profile of CBZ was studied. Characterization
of hot‑melt extruded samples was done by Fourier transform infrared spectroscopy (FTIR), differential scanning
calorimetry (DSC), and X‑ray diffraction studies (XRD). The result of the study showed the conversion of crystalline form
of drug into amorphous form indicating increase in saturation solubility and dissolution rate of CBZ.
Key words: Carbamazepine, hot‑melt extrusion, hydroxypropyl methyl cellulose

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