Some physicochemical properties of acetaminophen pediatric suspensions formulated with okra gums obtained from different extraction processes as suspending agent

Ogaji Ikoni

Abstract


The purpose of this work was to evaluate the effect of the extraction process and the potential of okra gum as a suspending agent in pharmaceutical oral formulations containing acetaminophen as a model drug. Clarified mucilage of dried okra was either extracted directly with ethanol 96% (F1) or was first treated with base (F2), acid (F3) or heating in the presence of salt (F4) before extraction with ethanol 96%. The samples were used at 0.5% w/v as suspending agents in
acetaminophen acetaminophen suspension to deliver 125 mg/5 mL acetaminophen. A binary mixture of F2 and F4 (1:1) was also used. Similar suspensions of acetaminophen containing either hydroxymethylpropylcellulose (HPMC) or tragacanth gum (TRAGA) were produced. Some physicochemical properties of the formulations were evaluated. The rheological properties of acetaminophen-containing treated okra gums (F2-F5) were generally similar. Changes in viscosity with storage were slower in the F2-F5 formulations as compared with F1. Particle size and particle size distribution were different for all
formulations, and hysteresis was a function of time and the suspending agent used.The re-dispersion time of the formulations with treated okra gums was generally shorter than that observed with the untreated okra gum. The use of a binary mixture of F2 and F4 resulted in different physicochemical properties from those of either F2 or F4.The physicochemical properties of the formulations were comparable to those with HPMC and TRAGA. It can thus be concluded that treating okra gum with acid, base or salt impacted better physicochemical properties on an acetaminophen pediatric suspension when they
were used as suspending agents.


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References


Ndjouenkeu R, Akingbala J, Oguntimein G. Emulsifying properties

of three African food hydrocolloids: Okra (Hibiscus esculentus), dika

nut (Irvingia gabonensis), and khan (Belschmiedia sp.). Plant Foods

for Human Nutrition (Formerly Qualitas Plantarum) 1997;51:245-55.

Udayasekhara Rao P. Chemical composition and biological evaluation

of Okra (andlt;iandgt;Hibiscus esculentusandlt;/iandgt;) seeds and their

kernels. Plant Foods Hum Nutr 1985;35:389-96.

Acquistucci R, Francisci R. Effect of okra (Hibiscus esculentus L.) addition

on the technological properties of a wheat flour. Int J Food Sci Nutr

;53:375-9.

Al-Wandawi H. Chemical composition of seeds of two okra cultivm. J

Agric Food Chem 1983;31:1355.

Falade KO, Omojola BS. Effect of processing methods on physical,

chemical, rheological, and sensory properties of okra (Abelmoschus

esculentus). Food Bioproc Technol 2010;3:387-94.

Inyang UE, Ike CI. Effect of blanching, dehydration method and

temperature on the ascorbic acid, colour, sliminess and other

constituents of okra fruit. Int J Food Sci Nutr 1998;49:125-30.

Kalra CL, Raina BL, Testia MS, Pruthi JS, Sharma BR, Nandpuri KS. The

influence of varieties on the quality of dehydrated okra. Indian Food

Packer 1983;37:47.

Ndjouenkeu R, Goycoolea FM, Morris ER, Akingbala JO. Rheology

of okra (Hibiscus esculentus L) and dikanut (Irvingia gabonensis)

polysaccharides. Arbohydr Polym 1996;29:263.

Olorunda AO, Tung MA. Rheology of fresh and frozen okra dispersions.

Int J Food Sci Technol 1977;12:593-8.

Romanchik-Cerpovicz JE, Costantino AC, Gunn LH. Sensory Evaluation Ratings and Melting Characteristics Show that Okra Gum Is an

Acceptable Milk-Fat Ingredient Substitute in Chocolate Frozen Dairy

Dessert. J Am Diet Assoc 2006;106:594-7.

Romanchik-Cerpovicz JE, Tilmon RW, Baldree KA. Moisture retention

and consumer acceptability of chocolate bar cookies prepared with okra

gum as a fat ingredient substitute. J Am Diet Assoc 2002;102:1301-3.

Savello PA, Marin FW, Hill JM. Nutritional composition of okra seed

meal. J Agric Food Chem 1980;28:1163.

Sengkhamparn N, Sagis L, De Vries R, Schols HA, Sajjaanantakul T, Voragen AG. Physicochemical properties of pectins from okra (Abelmoschus esculentus (L.) Moench). Food Hydrocolloids 2010;24:35-41.

Stone MB, Toure D, Greig JK, Naewbaniji JO. Effect of pretreatment and dehydration temperature on colour, nutrient retention and sensory

characteristics of okra. J Food Sci 1986;51:1201.

Uzo JO, Ojiako GU. A physical method for measuring okra fruit quality.

J Food Sci 1980;45:390.

Nasipuri RN, Igwilo CI, Brown AS, Kunle OO. Mucilage from Abelmoschus

esculentus (okra) fruits: A potential pharmaceutical raw material; part I;

physicochemical properties. J Pharma Res Dev1996;1:22-8.

Tavakoli N, Ghasemi N, Taimouri R, Hamishehkar H. Evaluation of okra

gum as a binder in tablet dosage forms. Iranian J Pharm Res Supple

;2:47.

Momoh MA, Adikwu MU, Ogbona JI, Nwachi UE. In Vitro Study of Release

of Metronidazole Tablets Prepared from Okra Gum, Gelatin Gum and

their Admixture. Bio Res 2009;6:339.

Kalu VD, Odeniyi MA, Jaiyeoba KT. Matrix properties of a new plant gum

in controlled drug delivery. Arch Pharm Res 2007;30:884-9.

Ogaji I, Nnoli O. Film coating potential of okra gum using paracetamol

tablets as a model drug. Asian J Pharma 2010;4:130-4.

Attama AA, Adikwu MU, Amorha CJ. Release of indomethacin from

bioadhesive tablets containing Carbopol ® 941 modified with

Abelmuschus esculentus (Okra) gum. Boll Chim Farm 2003;142:298.

Burgalassi S, Perini G, Giannaccini B, Saettone MF, Lodi A. Formulation

and stability of suspensions for preclinical study. Boll Chim Farm

;136:628-34.

Femi-Oyewo MN, Adedokun MO, Olusoga TO. Evaluation of the

suspending properties of Albizia zygia gum on sulphadimidine

suspension. Trop J Pharma Res 2004;3:279-84.

Nayak AK. Evaluation of Sinach aleracea L. Leaves mucilage as an

innovative suspending agent. J Adv Pharma Technol Res 2010;1:338-41.

Mahmud HS, Oyi AR, Allagh TS, Gwarzo MS. Evaluation of the

suspension property of kyaha sengalensis gum in cotrimoxazole

suspensions. Res J Appl Sci Engg Technol 2010;2:50-5.

Deveswaran R, Sharon F, Bharat S, Sindhu A, Basavaraj BV, Madhavan

V. Isapgol as a potential natural suspending agent. Int J Res Ayurveda

Pharma 2010;1:543-8.




DOI: http://dx.doi.org/10.22377/ajp.v5i1.79

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