Formulation and evaluation of immediate release tablet using response surface methodology

Sandeep C Atram


The purpose of the present work was to develop an optimized immediate release tablet for hypertensive patients using amlodipine besylate as a model drug candidate by optimization technique to produce the intended benefits. A 32 factorial design was employed in formulating immediate release tablet.The independent variables selected were superdisintegrants such as sodium starch glycolate and in addition to that, effect of microcrystalline cellulose was studied. The dependent variables considered for study was DT and DP60. The tablets prepared were evaluated for thickness, uniformity of weight, hardness, friability, wetting time, in vitro disintegration time, and in vitro drug release study. The response surface plots differentiate the results between the independent and dependent variables. Apart from fulfilling all official and other specifications, the
tablets exhibited higher rate of release.

Full Text:



Atram SC, Shahi SR, Udavant YK, Salunke RJ, Neb GB, Gulecha BS, et al.Formulation of bilayer tablet conatining metoprolol succinate and

amlodipine besylate as a model drug for antihypertensive therapy. J

Pharmacy Res 2009;2:1335-47.

Chandira M, Pasupathi A, Elamathi P, Bhowmik D, Chiranjib, Jayakar PB,

et al. Design, development and optimization of amlodipine besylate

tablets. Schloar Research Library. Der Pharmacia Lettre 2010;2:528-39.

Tangalos EG, Zarowitz BJ. Combination drug therapy. J Am Med Dir

Asso 2005;6:406-9.

Shiyani BG, Dholkiya RB, Akbari BV, Lodhiya DJ, Ramani GK.

Development and evaluation of novel immediate release tablets of

metoclopropamide hcl by direct compression using treated gellan gum

as a disintegration-accelaerating agent. J Pharmacy Res 2009;2:1460-4.

Rai VK, Pathak N, Bhaskar R, Nandi BC, Dey S, Tyagi LK. Optimizaton

of immediate release tablets of raloxifene hcl by wet grannulaton

method. International Journal of Pharmaceutical Sciences and Drug

Research 2009;1:51-4.

Patil SB, Shahi SR, Atram SC, Yoganand UK. Formulation and evaluation

of quick dispersible tablets of olenzapine. International Journal of

Pharmaceuitcal Research and Development-Online 2009;7:001

Shahi SR, Agrawal GR, Shinde NV, Shaikh SA, Padalkar AN, Somani

VG. Formulation design and optimization of orodispersible tablets

of etoricoxib by response surface methodology. Asian J Pharm


Rane Y, Mashru R, Sankalia M, Sankaliya J. Effect of hydrophilic swellable

polymers on dissolution ehancement of cabamazepine solid dispersion

studied using response surface methodology. AAPS PharmSciTech


Sinko PJ. Martin’s physical pharmacy and pharmaceutical sciences. 5th

ed. Baltimore: Lipincott williams and wilkins publication; 2006. p. 553-9.

Subramanyam CV. Textbook of physical pharmaceutics. 2 nd ed.

Pitampura, Delhi: Vallabh prakashan; 2000. p. 210-28.

Kumari S, Visht S, Sharma P. Preparation and evaluation of fast

disintrating tablets of dicylamine hcl. Scholar Research Library. Der

Pharmacia Lettre 2010;2:342-51.

Shirsand SB, Suresh A, Swamy PV, Para MS, NagendraKumar D.

Formualtion design of fast disintegrating tablets using disintegrant

blends. Indian J Pharm Sci 2010;72:131-3.

Aulton ME. Pharmaceutics the science of dosage form design. 2nd ed.

New York: Churchill livingstone publication; 2002. p. 417-22.

Lachman A, Lieberman HA, Kanig JL. The theory and pratice of industrial

pharmacy. 3rd ed. Bombay, India: Varghese publication house; 1971.


Joythi JB, Suneela G. Development of fast dissolving tablets of

glibenclamide using crospovidone and its kneading mixture. Indian J

Pharm Educ Res 2010;44:334-40.

Rao RN, Kota R, Shetty CM, Rao PK. Development and evaluation of

fast dissolving chlorthalidone tablets. International Journal of Pharmacy

and Pharmaceutical Sciences. International Journal of Pharmacy and

Pharmaceutical Sciences (IJPPS) 2009;1:80-7.

Wagh MP, Yewale CP, Zate SU, Kothawade PI, Mahale GH. Development

and evaluation of fast dispersible tablets of aceclofenac using

different superdisintegrant. International Journal of Pharmacy and

Pharmaceutical Sciences (IJPPS) 2010;2:155-7.

Jacob S, Shirwarkar AA, Joseph A, Shrinivasan KK, Novel co-processed

excipients of mannitol and microcystalline cellulose for preparing

fast dissolving tablets of glipizide. Indian J Pharm Sci 2007;69:633-9.

Mohsin AA, Nimbalkar NE, Sanaullah S, Aejaz A, Formulation and

evaluation of mouth dissolving tablets of amitriptyline hydrochloride

by direct compression technique. International Journal of Pharmacy

and Pharmaceutical Sciences International Journal of Pharmacy and

Pharmaceutical Sciences (IJPPS) 2010;2:204-10.

Ishikawa T, Watanabe Y, Utoguchi N, Matsumoto M. Preparation

of tablets rapidly disintegrating in saliva containing bitter taste

masked grannules by compression method. Chem Pharm Bull (Tokyo)


Keny RV, Desouza C, lourenco CF. Formulation and evaluation of

rizatriptan benzoate mouth dissolving tablets. Indian J Pharm Sci




  • There are currently no refbacks.