A study of oleic acid oily base for the tropical delivery of dexamethasone microemulsion formulations

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M Bajpai
P K Sharma
A Mittal


Dexamethasone Microemulsion systems composed of Water, oleic acid;Tween 80 and Isopropyl alcohol were investigated as potential drug delivery vehicles. Pseudo-ternary phase diagram was constructed at room temperature by titration, and the oil-to-surfactant/co-surfactant mass ratios (O/SC) that exhibit the maximum in the solubilization of water were found. Microemulsion formulations were evaluated for pseudo ternary phase study, Globule size, thermal stability, centrifugation stress testing, specific gravity, pH study, in vitro release on rat abdominal skin.The permeation data showed that microemulsion
formulations increased dexamethasone flux 200–400 fold over the control, but permeability coefficients were decreased by 4 times.The superior transdermal flux of dexamethasone was due to 1000 fold improvement in solubilization of dexamethasone by microemulsions using lecithin. It can be concluded from the study that the dexamethasone microemulsions can be potentially used for improved topical drug delivery.


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Bajpai, M., Sharma, P. K., & Mittal, A. (2014). A study of oleic acid oily base for the tropical delivery of dexamethasone microemulsion formulations. Asian Journal of Pharmaceutics (AJP), 3(3). https://doi.org/10.22377/ajp.v3i3.267


Eccleston GM. Encyclopedia of pharmaceutical technology. In: Swarbric I,

Boylar JC, editors. Vol. 9. Marcel Dekker; New York: 1992. p. 375-421.

Hiemenz PC. Principles of colloid and surface chemistry. New York:

Marcel Dekker; 1986. p. 46.

Hiemenz PC, Rajagopalan R. Principles of colloid and surface chemistry.

rd ed. New York: Marcel Dekker; 1997. p. 213.

. Suryawanshi S, Singh SK, Gupta RC. A sensitive and selective HPLC/ SI- S/E M MS assay for the simultaneous quantification of dexamethasone.

J Chromatogr B Analyt Technol Biomed Life Sci 2006;830:54-63.

. Å koviera F. Microemulsions as vehicles for transdermal Permeation of

drugs. Acta Facult Pharm Univ Comenianae 2003;50:147-55.

Shaji J, Joshi V. Self-micro emulsifying drug delivery system (SMEDDS)

for improving bioavailability of hydrophobic drugs and its potential

to give sustain release dosage form. Indian Journal of Pharmaceutical

Education 2005;39:130-5.

Jadhav KR, Shaikh IM, Ambade KW, Kadam VJ. Applications of

microemulsion based drug delivery system. Curr Drug Deliv

;3:267- 3.

Derle DV, Sagar BS, Pimpale S. Microemulsion as a vehicle for

transdermal permeation of nimesulide. Ind J Phar Sci 2006;68:622-5.

Bali V, Bhavna, Ali M, Baboota S, Ali J. Potential of microemulsions in

drug delivery and therapeutics: A patent review. Recent Pat Drug Deliv

Formul 2008;2:136-44.

Razdan R, Devrajan PV. Microemulsion-a review. Indian Drugs


Lawrence MJ, Rees GD. Microemulsion-based media as novel drug

delivery systems. Adv Drug Deliv Rev 2000;45:89-121.

Ranade VV. Drug delivery systems through transdermal delivery. J Clini

Pharmacol 1991;31:401-18.

Sintov AC, Shapiro L. New microemulsion vehicle facilitates

precutaneous penetration in vitro and cutaneous drug bioavailability

in vivo. J Control Release 2004;95:173-83.

Chen H, Chang X, Weng T, Zhao X, Gao Z, Yang Y, et al. A study of

microemulsion systems for transdermal delivery of triptolide. J Control

Release 2004;98:427-36.