Development and evaluation of novel trans- buccoadhesive bilayer tablets of Famotidine

M Alagusundaram, C Madhusudhana Chetty, D Dhachinamoorthi

Abstract


The present investigation highlights the novel trans-buccoadhesive tablets of Famotidine, an H2-receptor antagonist used as an antiulcerative agent. The buccoadhesive tablets were prepared by direct compression method using bioadhesive polymers like sodium alginate, SCMC, HPMC-K100M, PVP-K30 either alone or in combinations with EC as a backing layer.The prepared formulations were evaluated for their physicochemical characteristics, swelling index, surface pH, ex vivo buccoadhesive strength, in vitro, in vivo drug release and ex vivo permeation studies. The distinguishable differences in the results were shown to be dependent on characteristics and composition of bioadhesive materials used. Stability studies were performed in natural human saliva and accelerated conditions showed no significant difference in physical appearance, drug
content, buccoadhesive strength and the P-value statistically significant at <0.05. Ex vivo mucous irritation by histological examination reveals, the administration site of buccal tablet over the buccal mucosa did not cause any irritation, ulceration, inflammation and redness, and it resembles to controlled buccal mucosa. Good correlations were observed between in vitro and in vivo drug release, with a correlation coefficient of 0.996. Drug diffusion from buccal tablets showed apparently zero order kinetics and release mechanism was diffusion controlled after considerable swelling.


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DOI: http://dx.doi.org/10.22377/ajp.v5i3.100

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