Paclitaxel loaded poly(sebacic acid-co-ricinoleic ester anhydride)-based nanoparticles
Main Article Content
Abstract
displacement technique. The prepared formulations were characterized in terms of particle size and distribution, surface morphology using Malvern laser analyzer, scanning electron microscope (SEM). Drug physical and chemical state were
determined by Fourier transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD) and differential scanning calorimetry. The particles obtained were spherical in shape with a smooth surface and mean particle size in the range of
443-436 nm. The entrapped PTX within the polymer matrix was in the form of amorphous state.
Downloads
Article Details
This is an Open Access article distributed under the terms of the Attribution-Noncommercial 4.0 International License [CC BY-NC 4.0], which requires that reusers give credit to the creator. It allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, for noncommercial purposes only.
References
Jemal R, Siegel E, Ward YP, Hao JQ, Xu T, Murray MJ. Cancer statistics.
CA Cancer J Clin 2008;58:71-96.
Farokhzad OC, Langer R. Impact of nanotechnology on drug delivery.
Nano Lett 2009:3;16-20.
Rai S, Paliwal R, Gupta PN, Khatri K, Goyal AK, Vaidya B, et al. Solid lipid nanoparticles (SLNs) as a rising tool in drug delivery science: one step
up in nanotechnology. Curr Nanosci 2008;4:30-44.
Tong R, Cheng JJ. Anticancer polymeric nanomedicines. Polymer Rev
;47:3450-81.
Zhang LF, Gu FX, Chan JM, Wang AZ, Langer R, Farokhzad OC.
Nanoparticles in medicine: Therapeutic applications and developments.
Clin Pharmacol Ther 2008;83:761-9.
Kwon G, Suwa S, Yokoyama M, Okano T, Sakurai Y, Kataoka K. Enhanced tumor accumulation and prolonged circulation times of micelle-forming poly (ethylene oxide-aspartate) block copolymer-adriamycin conjugates. J Control Release 1994;29:17-23.
Cabral H, Nishlyama N, Kataoka K. Optimization of (1, 2-diamino-
cyclohexane) platinum (II)-loaded polymeric micelles directed to
improved tumor targeting and enhanced antitumor activity. J Control
Release 2007;121:146-55.
Owens DE, Peppas NA. Opsonization, biodistribution and
pharmacokinetics of polymeric nanoparticles. Int J Pharm
;307:93-102.
Li SD, Huang L. Pharmacokinetics and biodistribution of nanoparticles.
Mol Pharm 2008;5:496-504.
Singla AK, Garg A, Aggarwal D. Paclitaxel and its formulations. Int J
Pharm 2002;235:179-92.
Brigger C, Dubernet P, Couvreur. Nanoparticles in cancer therapy and
diagnosis. Adv Drug Deliv Rev 2002;54:631-51.
Katti DS, Lakshmi S, Langer R, Laurencin CT. Toxicity, biodegradation
and elimination of polyanhydrides. Adv Drug Deliv Rev 2002;54:933.
Krasko MY, Shikanov A, Ezra A, Domb AJ. Poly (ester anhydride) prepared by the insertion of ricinoleic acid into poly (sebacic acid). J Polym Sci Part A Polym Chem 2003;41:1059-69.
Agueros M, Ruiz-Gaton L, Vauthier C, Bouchemal K, Espuelas S,
Ponchel G, et al. Combined hydroxypropyl-e-cyclodextrin and poly
(anhydride) nanoparticles improve the oral permeability of paclitaxel.
Eur J Pharm Sci 2009;38:405-13.
Costa P, Lobo JM. Modeling and comparison of dissolution profiles.
Eur J Pharm Sci 2001;13:123-33.
Sahana K, Santra S, Mukherjee B. Development of biodegradable
polymer based tamoxifen citrate loaded nanoparticles and effect of
some manufacturing process parameters on them: A physicochemical
and in vitro evaluation. Int J Nanomedicine 2010;5:621-30.
Shikanov AE, Domb AJ. Poly (sebacic acid-co-ricinoleic acid)
biodegradable carrier for paclitaxel-effect of additives. J Control Release
;10:552-67.