Designing of superporous cross-linked hydrogels containing acrylic-based polymer network

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Debajyoti Ray
Prafulla Kumar Sahoo
Guru Prasad Mohanta


Biodegradable cross-linked polymer, 2-hydroxyethyl methacrylate-co-acrylic acid was synthesized by free radical polymerization technique using N,Nâ€-methylene-bis-acrylamide as cross-linker and benzoyl peroxide as reaction initiator.
FT-IR, 1H-NMR, scanning electron microscopy (SEM), and thermogravimetric analysis (TGA) studies of the copolymer along with homopolymers were carried out. FT-IR studies showed no interactions on copolymerization. SEM studies of the
copolymer were carried out and mean particle size was found to be 50 μm. TGA analysis indicated an increase in thermal stability by cross-linking the polymer network. Swelling behavior of the copolymer showed more swelling by increasing pH of the medum and the prepared polymer was found to be biodegradable. The prepared cross-linked polymer system holds good for further drug delivery studies in connection to its super swelling and biodegradability.


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Ray, D., Sahoo, P. K., & Mohanta, G. P. (2014). Designing of superporous cross-linked hydrogels containing acrylic-based polymer network. Asian Journal of Pharmaceutics (AJP), 2(2).


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