Design and evaluation of the fast dissolving tablet of terbutaline sulfate

Manivannan Rangasamy, Balasubramaniam Ayyasamy, Senthilkumar Raju, Sandeep Gummadevelly

Abstract


Asthma is an inflammatory disorder that results in the obstruction of air pathways and causes difficulty in breathing. Oral dosage forms associated with lag time and delayed onset of action are among the available means of treatment. However,
aerosols and parenterals have a rapid onset of action but strongly affect the patient compliance.Thus, an attempt was made to improve the onset of action of bronchodilator used commonly in the treatment of asthma. Fast dissolving tablets of terbutaline sulfate were prepared by the direct compression method after incorporating superdisintegrants such as Explotab, Ac-Di-Sol and Polyplasdone XL in different concentrations.The prepared tablets were evaluated for weight variation, thickness, hardness, friability, wetting time, drug content, water absorption ratio, in vitro dispersion time, in vitro disintegration time and in vitro
drug release. Among all, the formulation F9 (containing 5% w/w concentration of Polyplasdone XL) was considered to be the best formulation, which releases up to 99.33% of the drug in 10 min.


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References


Lindgren S, Janzon L. Dysphagia: Prevalence of swallowing complaints

and clinical finding. Med Clin North Am 1993;77:3-5.

Sastry SV, Nyshadham JR, Fix JA. Recent technological advances in oral

drug delivery: A review. Pharm Sci Technol Today 2000;3:138-45.

F9

56

69

21

26

56

33

Conventional

tablet

26

26

47

23

63

12

Bradley JU, Lawrence ML. Drugs used in the treatment of

asthma. In: Hardman JG, Lee E, editors. Goodman and Gilman’s:

The Pharmacological basis of therapeutics. 10 th ed. New York:

The Mc Graw- ill Companies; 2001. p. 735.

H

Kucherkar BS, Badhan AC, Mahajan HS. Mouth dissolving tablets of

salbutamol sulphate: A novel drug delivery system. Indian Drugs

;41:592-8.

Banker GS, Anderson NR. In: Lachman L, Liberman HA, Kanig JL,

editors. The theory and Practice of industrial pharmacy. 3rd ed. Mumbai:

Varghese Publishing House; 1987. p. 297.

Indian Pharmacopoeia. Vol. 2. Delhi: The Controller of Publications;

p. A-80.

Arias MJ, Gines JM, Moyano JR, Perez-Martinez JI, Rabasco AM. Influence

of preparation method of solid dispersions on dissolution rate: Study

of triammterene-D- mannitol system. Int J Pharm 1995;123:25-31.

Yunxia B, Sunada H, Yonezawa Y, Danjo K. Evaluation of rapid

disintegrating tablets prepared by direct compression method. Drug

Dev Ind Pharm 1999;25:571.

Chaudhari PD, Chaudhari SP, Kolhe SR, Dave KV, More DM. Formulation

and evaluation of fast dissolving tablet of famotidine. Indian Drugs

;42:641-9.

Kuchekar BS, Arumugam V. Fast dissolving tablets. Indian J Pharm Edu

;35:150.




DOI: http://dx.doi.org/10.22377/ajp.v3i3.268

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