Formulation and evaluation of irbesartan fast dissolving tablets

Anne Ramu, Suyadevara Vidyadhara, Nayakanti Devanna1, Uttlapalli Thirumala Naidu, Pavuluri Lakshmi Kalyani


Solid dispersions of irbesartan with poly ethylene glycol (PEG‐6000) were prepared and further compressed as tablets by using superdisintegrants such as croscarmellose sodium, crospovidone, sodium starch glycolate (SSG). The solid
dispersions of irbesartan with PEG‐6000 at different ratios were prepared by physical mixing, solvent evaporation and kneading methods. The rapid release of poorly soluble irbesartan from solid dispersions was influenced by the proportion
of polymer and the method employed for its preparation. Among the three methods employed kneading method was found to be suitable for improving the dissolution rate of irbesartan. The release was found to follow the first order kinetics.Solid dispersions prepared by the kneading method were further formulated into tablets with superdisintegrants such as croscarmellose sodium, crospovidone, SSG. All the tablet preparations containing superdisintegrants were formed to release the drug in the order SSG > cross carmellose sodium > cross povidone. The dissolution rate of such tablet formulations were found to release the drug at a faster rate than the tablets prepared with plain drug.

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Lachman L, Liberman HA. Theory and Practice of Industrial Pharmacy.

rd ed. Mumbai: Varghese Publishing House; 1998. p. 295‐8.

Streubel A, Siepmann J, Bodmeier R. Drug delivery to the upper small

intestine window using gastroretentive technologies. Curr Opin

Pharmacol 2006;6:501‐8.

Desai J, Alexander K, Riga A. Characterization of polymeric dispersions

of dimenhydrinate in ethyl cellulose for controlled release. Int J Pharm


Malviya R, Srivasthava P, Bansal M, Sharma PK. Improvement of

dissolution behavouir of paracetmol using solid dispersion technique.

Int J Pharm Sci Res 2010;1:95‐9.

Lipinski CA. Avoiding investment in doomed drugs, is poor solubility

an industry wide problem. Current Drug Discov 2001;4:17‐9.

Someshwar K, Chithaluru K, Ramarao T, Kumar KK. Formulation and

evaluation of effervescent floating tablets of tizanidine hydrochloride.

Acta Pharm 2011;61:217‐26.

Muhrer G, Meier U, Fusaro F, Albano S, Mazzotti M. Use of

compressed gas precipitation to enhance the dissolution behavior of

a poorly water‐soluble drug: Generation of drug microparticles and

drug‐polymer solid dispersions. Int J Pharm 2006;308:69‐83.

Prashant S, Prashant S, Narkhede M. Solubility enhancement of

diacerein by mannitol solid dispersons. Int J Pharm Pharma Sci


Chiou WL, Riegelman S. Pharmaceutical applications of solid dispersion

systems. J Pharm Sci 1971;60:1281‐302.

Renu C, Sushma G, Natasha P. Binary and ternary complexes of arteether β‐CD – characterization, molecular modeling and in vivo studies. SciRes 2011;2:212‐25.



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