Main Article Content
enhance the stability of the vesicles and to prove the efficacy of the liposome in promoting the antipyretic activity of the drug. The liposome formulation was found to be more effective than the marketed antipyretic drug. A 1.5% CP could be considered as the minimum concentration for the gel to maintain the liposome stable than a 0.5% CP polymer.The surfactant, Polysorbate 80, helped to form spherical vesicles and CP polymer-1.5% w/w was found to show enhanced stability of the formulation.The concentration of 1.5% CP seemed to give the necessary mechanical strength to the liposomal formulation. A drug delivery system by the modified liposomes may be considered for further investigation for validating and standardizing this formulation for the controlled drug release system toward enhancing maximum therapeutic efficacy.
This is an Open Access article distributed under the terms of the Attribution-Noncommercial 4.0 International License [CC BY-NC 4.0], which requires that reusers give credit to the creator. It allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, for noncommercial purposes only.
SchÃ¤fer-Korting M, Mehnert W, Korting HC. Lipid nanoparticles for
improved topical application of drugs for skin diseases. Adv Drug Deliv
Moghimi SM, Patel HM. Current progress and future prospects of
liposomes in dermal drug delivery. J Microencapsul 1993;10:155-62.
Rawat M, Singh D, Saraf S, Saraf S, Yakugaku Zasshi. Lipid carriers: A
versatile delivery vehicle for proteins and peptides. Curr Drug Deliv
Kao HJ, Lin HR, Lo YL, Yu SP. Characterization of pilocarpine-loaded
chitosan/Carbopol nanoparticles. J Pharm Pharmacol 2006;58:179-86.
Qi H, Chen W, Huang C, Li L, Chen C, Li W, Wu C. Development of a
poloxamer analogs/carbopol-based in situ gelling and mucoadhesive
ophthalmic delivery system for puerarin. Int J Pharm 2007;337:178-87.
Wilson B, Samanta MK, Santhi K, Kumar KP, Paramakrishnan N, Suresh B.Poly(n-butylcyanoacrylate) nanoparticles coated with polysorbate 80 for
the targeted delivery of rivastigmine into the brain to treat Alzheimerâ€™s
disease. Brain Res 2008;1200:159-68.
Sinico C, Caddeo C, Valenti D, Fadda AM, Bilia AR, Vincieri FF. Liposomes
as carriers for verbascoside: Stability and skin permeation studies
J Liposome Res 2008;18:83-90.
Cevc G, Blume G. Biological activity and characteristics of triamcinolone-
acetonide formulated with the self-regulating drug carriers,
Transfersomes. Biochim Biophys Acta 2003;1614:156-64.
Samad A, Sultana Y, Aqil M. Liposomal drug delivery systems: An update review. Curr Drug Deliv 2007;4:297-305.
Elorza B, Elorza MA, Frutos G, Chantres JR. Characterization of
-fluorouracil loaded liposomes prepared by reverse-phase evaporation
or freezing-thawing extrusion methods: study of drug release. Biochim
Biophys Acta 1993;1153:135-42.
Hossann M, Wiggenhorn M, Schwerdt A, Wachholz K, Teichert N,
Eibl H, et al. in vitro stability and content release properties of
phosphatidylglyceroglycerol containing thermosensitive liposomes.
Biochim Biophys Acta 2007;1768:2491-9.
DragiÄ‡eviÄ‡-CuriÄ‡ N, Stupar M, MiliÄ‡ J, ZoriÄ‡ T, Krajisnik D, VasiljeviÄ‡ D.
Hydrophilic gels containing chlorophyllin-loaded liposomes:
development and stability evaluation. Pharmazie 2005;60:588-92.
Mourtas S, Fotopoulou S, Duraj S, Sfika V, Tsakiroglou C, Antimisiaris SG. Liposomal drugs dispersed in hydrogels. Effect of liposome, drug and
gel properties on drug release kinetics. Colloids Surf B Biointerfaces
PaveliÄ‡ Z, Skalko-Basnet N, Jalsenjak I. Characterisation and in vitro
evaluation of bioadhesive liposome gels for local therapy of vaginitis.
Int J Pharm 2005;14:140-8.
Takeuchi H, Matsui Y, Yamamoto H, Kawashima Y. Mucoadhesive
properties of carbopol or chitosan-coated liposomes and their
effectiveness in the oral administration of calcitonin to rats. J Control
Patel VB, Misra AN, Marfatia YS. Preparation and comparative clinical
evaluation of liposomal gel of benzoyl peroxide for acne. Drug Dev Ind