Differential Scanning Calorimeter Profiling for the Determination of Nanoparticle Ethanol Extract of Clove (Syzygium aromaticum L.) Toward Michigan Cancer Foundation-7 Human Breast Cancer Cell Lines

Fadilah Fadilah


Aim: This research was conducted to evaluate in vitro assay of nanoparticles ethanol extract of cloves toward Michigan Cancer Foundation-7 human breast cancer cell lines. Materials and Methods: In this research, we have synthesized bud clove extract nanoparticles and analyzed with differential scanning calorimetry. The cytotoxic activity of extract, nanoparticles, and its bioactive component was investigated with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and analyzed by ELISA reader. Results: The in vitro test showed that the IC50 values of the extract and the nanoparticles were 20.13 μg/mL and 7.6 μg/mL, respectively. Conclusion: The ethanol extracts of clove (Syzygium aromaticum L.) could be formulated in nanoparticles form. From cytotoxicity assay, nanoparticle of clove extract showed better cytotoxic activity than the ethanol extract.

Full Text:


DOI: http://dx.doi.org/10.22377/ajp.v12i04.2950


  • There are currently no refbacks.