Mixed solvency concept in reducing surfactant concentration of self‐emulsifying drug delivery systems of candesartan cilexetil using D‐optimal mixture design

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Chandna Chandan
Maheshwari RK


The objective of this present study was to explore the utility of “mixed solvency†concept to enhance the solubility of poorlyâ€water soluble drug, candesartan cilexetil (CC) in modified solubilizer system. The objective of this paper is to
reduce the surfactant concentration traditionally involved in the formulation of selfâ€emulsifying drug delivery systems (SEDDS) by proposing an alternate system of solubilizer to provide novel surfactant/cosurfactant system, to aid traditionally involved components in the formulation of SEDDS.The present study showed that “mixed solvency†concept was successfully employed in solubility enhancement of CC in (Transcutol P: B3Mix [1:1]) up to 303 mg/g of blend. Present study demonstrated the promising use of “mixed solvency†concept in solubility enhancement of poorlyâ€water soluble drugs and tool to reduce the net surfactant concentration employed in designing of SEDDS.


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Chandan, C., & RK, M. (2014). Mixed solvency concept in reducing surfactant concentration of self‐emulsifying drug delivery systems of candesartan cilexetil using D‐optimal mixture design. Asian Journal of Pharmaceutics (AJP), 7(2). https://doi.org/10.22377/ajp.v7i2.31


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