Mixed solvency concept in reducing surfactant concentration of self‐emulsifying drug delivery systems of candesartan cilexetil using D‐optimal mixture design

Chandna Chandan, Maheshwari RK

Abstract


The objective of this present study was to explore the utility of “mixed solvency” concept to enhance the solubility of poorly‐water soluble drug, candesartan cilexetil (CC) in modified solubilizer system. The objective of this paper is to
reduce the surfactant concentration traditionally involved in the formulation of self‐emulsifying drug delivery systems (SEDDS) by proposing an alternate system of solubilizer to provide novel surfactant/cosurfactant system, to aid traditionally involved components in the formulation of SEDDS.The present study showed that “mixed solvency” concept was successfully employed in solubility enhancement of CC in (Transcutol P: B3Mix [1:1]) up to 303 mg/g of blend. Present study demonstrated the promising use of “mixed solvency” concept in solubility enhancement of poorly‐water soluble drugs and tool to reduce the net surfactant concentration employed in designing of SEDDS.


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DOI: http://dx.doi.org/10.22377/ajp.v7i2.31

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