Proportional Resonance and Fractionalorder Proportional Integral Derivativebased Closed-loop Drug Infusion for the Regulation of Mean Arterial Pressure in Critical Care Patients â€“ A Modeling and Simulation Study
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Aim: Managing hypertensive emergencies are a common occurrence in critical care setups. Mean arterial pressure
(MAP) is an important hemodynamic variable indicative of hypertensive control and its regulation and needs to
be controlled by a constrained set of physiological values. Materials and Methods: Sodium nitroprusside is a
potent vasoactive drug which is used in the critical care setups to regulate hypertensive emergencies, administered
through intravenous route. Many closed-loop drug infusion systems (CL-DIS) powered by fuzzy logic, artificial
neural networks, and state-space models have been used to regulate the infusion. In this work, an attempt using
proportional resonance controller and fractional-order proportional integral derivative (PID) with a closed loop
is modeled and simulated. Results and Discussion: This work proposes a CL-DIS-based proportional resonance
controller and fractional-order PID controller, which will respond rationally to the changes in the patientâ€™s
condition and activate drug infusion to continue the MAP at the set physiological values of 60 and 70 mmHg.
Conclusion: The planned controller setup has potential to be used as a controller for intravenous infusion of
drugs and in our work maintained the MAP constrained by set values for the time domain responses for ideal
physiological set points.
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