Formulation and Evaluation of Negatively Charged Liposomes of Sertraline Hydrochloride for Antidepressant Activity

Main Article Content

Ruchi Chawla

Abstract

Introduction: In the present study, liposomes of sertraline hydrochloride were formulated for use in depression. Materials and Methods: The liposomes were formulated by film hydration technique and were characterized for surface morphology, particle size, drug entrapment, and drug release potential. The antidepressant-like activity was studied using chronic unpredictable mild stress procedure and then further, the responsiveness toward treatment as measured by changes in swimming, immobility, and struggling behavior of rats. Results: Negatively charged liposomes with an average size of 154 nm showed controlled drug release. Behavioral studies on stress-induced rat model showed a significant increase in the swimming and immobility time and a decrease in the struggling behavior of animals in comparison to a marketed sertraline hydrochloride formulation. Conclusions: The antidepressant-like activity was studied using chronic unpredictable mild stress procedure and then further, the responsiveness toward treatment as measured by changes in swimming, immobility, and struggling behavior of rats.

Downloads

Download data is not yet available.

Article Details

How to Cite
Chawla, R. (2020). Formulation and Evaluation of Negatively Charged Liposomes of Sertraline Hydrochloride for Antidepressant Activity. Asian Journal of Pharmaceutics (AJP), 14(2). https://doi.org/10.22377/ajp.v14i2.3616
Section
ORIGINAL ARTICLES