Development, Characterization, and In vitro Evaluation of Aceclofenac Emulgel

Main Article Content

D. S. Sandeep


Aim: The present research work was aimed to develop a novel emulgel for aceclofenac to enhance the drug
absorption by the topical application, which overcomes the demerits of oral dosage form and conventional gel
system of aceclofenac. Materials and Methods: The emulgels were prepared with carbopol 934 as a gelling
agent used in six different concentrations. Span 20 and Tween 20 were included as emulsifying agents in two
different concentrations. Liquid paraffin was used as an oil phase, and methyl and propylparaben were included
as preservatives. Ethanol was used to dissolve the drug for preparing the aqueous phase and Triethanolamine was
added at the end of preparation, as quantity sufficient for pH adjustment. Results: All the formulated emulgels
were screened for the parameters, namely, appearance, pH, rheology study, spreadability, swelling index, drug
content, and in vitro drug release studies. The optimized formulation AG-4 showed 91.43% of drug release with
sustained-release manner up to 6 h, and the particle size analysis reported good size range, and the emulgel was
found to be nonirritant and nontoxic which was confirmed by HET CAM test. Conclusion: Aceclofenac can be
successfully formulated as emulgel for better-sustained effect and can be a suitable alternative approach to the oral
dosage forms for the management of arthritis.


Download data is not yet available.

Article Details

How to Cite
Sandeep, D. S. (2020). Development, Characterization, and In vitro Evaluation of Aceclofenac Emulgel. Asian Journal of Pharmaceutics (AJP), 14(03).