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Aim: This study aims to illustrate the prescribing trends of antihistamines in the outpatient setting in Al-Kharj.
Materials and Methods: This is a retrospective study that included the evaluation of antihistamines in the
outpatient setting in a public hospital in Al-Kharj. The data were collected from the pharmacy-based computer
system. Results: The total number of prescriptions that included antihistamines was 799. Most of the prescribed
antihistamines were first-generation sedating antihistamines (chlorphenamine and diphenhydramine)
(66.33%). About 63.20% of the prescribed antihistamines included chlorpheniramine followed by cetirizine
(19.27%) and loratadine (14.39%). Conclusion: Antihistamines were prescribed commonly in the outpatient
setting mainly first-generation sedating antihistamines. It is recommended to increase the awareness of healthcare
providers about the efficacy and the side effects of antihistamines and to encourage them to use these
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