A Review of Gelatine Formulations for Topical Skin Cancer Treatment

Abstract

Regarding both regional and widespread drugs, cancer of the skin, regardless of its manifestations, is the disease
with the highest incidence rate in the world. Topical chemotherapy is an intriguing therapeutic approach due to
its low cost and lack of invasiveness. Nonetheless, it is difficult to distribute antineoplastic drugs through the skin
due to the numerous methodologies that have been utilized to ascertain the physicochemical features, including
solubility, ionized molecular weight, and melting point, as well as the efficacy of the stratum corneum’s protective
barrier, utilized to increase drug absorption, retention, and effectiveness. Its objectives are to determine the most
popular methods for topical medication administration using gel-based medications for the treatment of skin
cancer. The preparation methods, the excipients employed, and the techniques for characterizing gels are briefly
explained. Safety considerations are also emphasized.