DRUG DELIVERY ENHANCEMENT STRATEGIES THROUGH CORNEA: A REVIEW
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Abstract
Eye is the specialized organ for photorecept ion that poses unique challenges for drug delivery. Eye
diseases can be t reated with systemic, int raocular and/ or topical administ rat ion of drugs. The review
highlights the challenges in ocular drug delivery through various routes with emphasis on topical route.
The corneal transport process for different drugs is also touched. Different approaches for drug delivery
enhancement through cornea are discussed with special at tent ion on chemical modificat ion (prodrug)
approach. Nutrient transporter targeted prodrug design approach are discussed with special reference to
amino acid prodrug design approach for enhanced drug delivery
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