AEROSOLIZED LIPOSOMES OF CROMOLYN SODIUM FOR ALVEOLAR TARGETING; PART II: FORMULATION AND CHARACTERIZATION
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Abstract
This is second par t of a three ar t icle ser ies on aerosolized liposome based lung target ing of cromolyn
sodium (CS) focusing on formulation and characterization aspects of the system. In total eleven product
s were formulated out of which one was designed to contain pre- formed liposomes of CS, one to
contain CS in proliposome form and nine to contain cet r imide- cromolyn conjugates (3C) dissolved in
propellant- phosphalipid solution. The pressure packs were characterized for aerosol parameters as well
as liposome parameters i.e. appearance, leak test , internal pressure, discharge rate, spray pat tern,
airways penetration efficiency and liposomal size.
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