PREPARATION AND EVALUATION OF MUCOADHESIVE BUCCAL FILMS OF CARVEDILOL

TALESARA A. TALESARA A.

Abstract


This research work was carried out t o study effect of ionic and non- ionic polymers on buccal films of
carvedilol. Solvent casting method was used for preparing mucoadhesive films of carvedilol using carboxymethyl
cellulose, polyvinyl pyrrolidone K-30 and polyvinyl alcohol and evaluated for their weight,
thickness, surface pH, swelling index, in vitro residence time, folding endurance, in vitro release, permeation
studies and drug content uniformity. F1 formulation (prepared from carboxymethyl cellulose) exhibited
good cont rolled release over six hours. Physical characterist ics of the studied films showed
promising with good bio-adhesion. Performance of ionic polymers was good when compared with nonionic
polymer.


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DOI: http://dx.doi.org/10.22377/ajp.v1i1.744

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